Serum resistin level is associated with radiographic changes in hand osteoarthritis: Cross-sectional study
Serum resistin level is associated with radiographic changes in hand osteoarthritis: Cross-sectional study
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DOI：
10.1016/j.jbspin.2011.04.009
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发表时间：
2012-03-01
期刊：
影响因子：
4.2
通讯作者：
Kim, Seong-Kyu
中科院分区：
文献类型：
--
作者：
Choe, Jung-Yoon;Bae, Jisuk;Kim, Seong-Kyu
目的：本研究的目的是确定脂联素和抵抗素等脂肪因子是否与手骨关节炎 (OA) 患者的放射学结果相关。方法：共有 156 名女性受试者（46 名对照者、60 名非放射手部 OA 和 50 名放射手部 OA）入组。我们使用酶联免疫吸附测定（ELISA）测量血清脂联素和抵抗素浓度。放射照相手部 OA 的定义是，对双手的 20 个关节进行评估后，存在 >= 2 Kellgren-Lawrence 放射学等级。使用控制混杂临床参数的多变量逻辑回归模型评估放射学手部 OA 与每种脂肪因子之间的关联。结果：放射学手部 OA 患者的血清抵抗素水平高于非放射学手部 OA 和对照者（分别为 p(adj) = 0.020 和 p(adj) = 0.019），而血清脂联素水平没有显着差异。手部 OA 影像学变化的存在取决于血清抵抗素水平 (p(adj) = 0.028）。具体而言，放射照相手 OA 的软骨下糜烂与血清抵抗素相关 (p(adj) = 0.028）。然而，血清脂肪因子与关节间隙狭窄、骨强直和皮质破坏没有关联。结论：本研究表明抵抗素参与手部 OA 的放射学变化，并且脂肪因子有助于手部 OA 放射学结果的发病机制。 (C) 2011 年法国风湿病学会。由 Elsevier Masson SAS 出版。版权所有。
Objective: The aim of this study was to determine whether adipokines such as adiponectin and resistin were related to radiographic outcomes in patients with hand osteoarthritis (OA).Methods: A total of 156 female subjects (46 controls, 60 non-radiographic hand OA, and 50 radiographic hand OA) were enrolled. We measured serum adiponectin and resistin concentrations using an enzyme-linked immunosorbent assay (ELISA). Radiographic hand OA was defined by the presence of a >= 2 Kellgren-Lawrence radiological grade after assessment for 20 joints of both hands. The association between radiographic hand OA and each adipokine was assessed using multivariate logistic regression models controlling for confounding clinical parameters.Results: Serum resistin levels in radiographic hand OA patients were higher than in non-radiographic hand OA and controls (p(adj) = 0.020 and p(adj) = 0.019, respectively), whereas there were no significant differences in serum adiponectin levels. The presence of radiographic changes in hand OA was shown to be dependent on serum resistin levels (p(adj) = 0.028). Specifically, subchondral erosion in radiographic hand OA was associated with serum resisitin (p(adj) = 0.028). However, there were no associations of serum adipokines with joint space narrowing, bony ankylosis, and cortical destruction.Conclusions: This study suggests that resistin is involved in radiographic changes in hand OA, and that adipokines contribute to pathogenesis in radiographic outcomes in hand OA. (C) 2011 Societe francaise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.