Practice effects and the use of alternate forms in serial neuropsychological testing
Practice effects and the use of alternate forms in serial neuropsychological testing
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DOI：
10.1016/j.acn.2004.12.003
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发表时间：
2005-06-01
影响因子：
2.6
通讯作者：
Siemers, ER
中科院分区：
文献类型：
--
作者：
Beglinger, LJ;Gaydos, B;Siemers, ER
准确理解神经心理学测试的实践特征、性能稳定性和误差对于认知增强药物临床试验的有效临床评估和最大化信号检测至关重要。我们研究了28名健康成年人的实践效果。作为使用多奈哌齐并模拟I期试验的更大研究的一部分，参与者被随机分为：安慰剂，无治疗和多奈哌齐。多奈哌齐结果见其他地方。神经心理学测试以固定的顺序进行6周，大多数测试都有替代形式。尽管有替代形式，但ANOVA显示，除字母编号测序和试验B外，合并对照组（安慰剂组和未给药组）的所有试验均显著改善。学习主要发生在最初的三到四节课。PASAT和Stroop干扰显示出最大的学习。因此，交替形式的系列评估可能会减弱某些测试的重考效应，但持续学习发生在新的测试或那些可以确定有利的考试策略。替代形式和基线实践会议可能有助于控制早期，快速改善临床试验。(c)2005年美国国家神经心理学学会。由爱思唯尔有限公司出版。保留所有权利。
Accurate understanding of practice characteristics, performance stability, and error on neuropsychological tests is essential to both valid clinical assessment and maximization of signal detection for clinical trials of cognitive enhancing drugs. We examined practice effects in 28 healthy adults. As part of a larger study using donepezil and simulating a Phase I trial, participants were randomized into: placebo, no-treatment and donepezil. Donepezil results are presented elsewhere. Neuropsychological tests were administered in a fixed order for 6 weeks, with alternate forms available for most tests. Despite alternate forms, ANOVAs revealed significant improvements for the pooled control group (placebo and no-treatment) on all tests except Letter Number Sequencing and Trails B. Learning occurred principally in the first three to four sessions. PASAT and Stroop interference showed the greatest learning. Thus, serial assessment with alternate forms may attenuate retest effects on some tests, but continued learning occurs on novel tests or those in which an advantageous test-taking strategy can be identified. Alternate forms and baseline practice sessions may help control early, rapid improvements in clinical trials. (c) 2005 National Academy of Neuropsychology. Published by Elsevier Ltd. All rights reserved.