Brain-adipose tissue neural crosstalk
Brain-adipose tissue neural crosstalk
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DOI：
10.1016/j.physbeh.2007.04.002
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发表时间：
2007-07-24
影响因子：
2.9
通讯作者：
Song, C. Kay
中科院分区：
文献类型：
--
作者：
Bartness, Timothy J.;Song, C. Kay
基础肥胖研究的优势集中在其发展受饮食和其他环境因素，遗传学及其相互作用的影响。相比之下，我们一直在研究西伯利亚仓鼠自然发生的季节性肥胖的逆转。在这项工作的过程中，我们确定，交感神经支配的白色脂肪组织（WAT）是主要的启动脂质动员不仅在这些动物，但在所有哺乳动物包括人类。我们提出了无可辩驳的证据，交感神经系统（SNS）神经支配的WAT的神经解剖学（包括其中央起源所揭示的transneuronal病毒道示踪剂），神经化学（去甲肾上腺素周转研究）和功能（手术和化学去神经）。WAT SNS神经支配的一个相对不受重视的作用也进行了审查-脂肪细胞增殖的控制所示的选择性化学去神经，触发脂肪细胞增殖，虽然目前发生的确切机制是未知的。然而，没有同样强有力的证据表明该组织的副交感神经支配;事实上，数据大部分是负面的，严重质疑其存在和重要性。令人信服的证据也给出了WAT的感觉神经支配（如由道跟踪和WAT中的感觉神经标记所示），提示性数据支持在向大脑传达肥胖程度信息中可能发挥的作用。总的来说，这些数据提供了一个额外的或替代的观点，占主导地位的一个控制体脂肪储存通过循环因素，作为传出和传入通信。(C)2007爱思唯尔公司All rights reserved.
The preponderance of basic obesity research focuses on its development as affected by diet and other environmental factors, genetics and their interactions. By contrast, we have been studying the reversal of a naturally-occurring seasonal obesity in Siberian hamsters. In the course of this work, we determined that the sympathetic innervation of white adipose tissue (WAT) is the principal initiator of lipid mobilization not only in these animals, but in all mammals including humans. We present irrefutable evidence for the sympathetic nervous system (SNS) innervation of WAT with respect to neuroanatomy (including its central origins as revealed by transneuronal viral tract tracers), neurochemistry (norepinephrine turnover studies) and function (surgical and chemical denervation). A relatively unappreciated role of WAT SNS innervation also is reviewed - the control of fat cell proliferation as shown by selective chemical denervation that triggers adipocyte proliferation, although the precise mechanism by which this occurs presently is unknown. There is no, however, equally strong evidence for the parasympathetic innervation of this tissue; indeed, the data largely are negative severely questioning its existence and importance. Convincing evidence also is given for the sensory innervation of WAT (as shown by tract tracing and by markers for sensory nerves in WAT), with suggestive data supporting a possible role in conveying information on the degree of adiposity to the brain. Collectively, these data offer an additional or alternative view to the predominate one of the control of body fat stores via circulating factors that serve as efferent and afferent communicators. (C) 2007 Elsevier Inc. All rights reserved.