Characteristics and prognosis of Japanese female breast cancer patients: The BioBank Japan project.
Characteristics and prognosis of Japanese female breast cancer patients: The BioBank Japan project.
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DOI：
10.1016/j.je.2016.12.009
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发表时间：
2017-03
影响因子：
4.7
通讯作者：
Tamakoshi A
中科院分区：
文献类型：
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作者：
Nakamura K;Okada E;Ukawa S;Hirata M;Nagai A;Yamagata Z;Kiyohara Y;Muto K;Kamatani Y;Ninomiya T;Matsuda K;Kubo M;Nakamura Y;BioBank Japan Cooperative Hospital Group;Tamakoshi A
乳腺癌是目前日本女性最常见的癌症类型。与大多数其他类型的癌症不同，乳腺癌在中年女性中的发病率高于老年女性。在2003年至2008年期间最初入选BioBank Japan项目的所有≥20岁的日本女性乳腺癌患者中，有2034例在诊断后90天内登记。我们描述了这些患者在研究入组时的生活方式和临床特征。此外，我们还研究了这些特征对全因死亡率的影响。在确诊后90天内登记的女性患者中，0期或未分类、I期、II期、III期和IV期的频率分别为11.4%、47.9%、37.0%、2.9%和0.8%。非浸润性癌（导管癌、小叶癌）占12.9%，浸润性癌（乳头状管状癌、实性管状癌、硬癌及特殊类型）占81.0%，佩吉特病占0.2%，其他占5.8%。雌、孕激素受体阳性率分别为75.8%和62.1%。在90天内登记的1860名女性参与者中，218名参与者在144，54人年的随访期间死亡。在校正年龄后，更晚期、血清癌胚抗原和碳水化合物抗原15-3水平升高以及研究入组时雌激素受体缺失与全因死亡风险增加粗略相关。这项研究显示了女性乳腺癌患者的几个临床特征与全因死亡率的相关性。大约1%的日本女性乳腺癌患者被诊断为IV期。浸润性癌较非浸润性癌多见。乳头状小管癌是最常见的浸润性癌。雌激素受体阳性率为75%，孕激素受体阳性率为60%。一些特征会影响乳腺癌患者的全因死亡率。
Breast cancer is currently the most common type of cancer in Japanese females. Unlike most other types of cancer, breast cancer develops more frequently in middle-aged females than in elderly females. Of all Japanese female breast cancer patients aged ≥20 years whom the BioBank Japan Project originally enrolled between 2003 and 2008, 2034 were registered within 90 days after their diagnosis. We described the lifestyle and clinical characteristics of these patients at study entry. Furthermore, we examined the effect of these characteristics on all-cause mortality. In the female patients registered within 90 days after diagnosis, the frequency of stage 0 or unclassified, stage I, II, III and IV were 11.4%, 47.9%, 37.0%, 2.9% and 0.8%, respectively. The proportion of histological types was 12.9% for non-invasive carcinoma (ductal carcinoma and lobular carcinoma), 81.0% for invasive carcinoma (papillotubular carcinoma, solid tubular carcinoma, scirrhous carcinoma and special types), 0.2% for Paget's diseases and 5.8% for others. Those positive for the estrogen and progesterone receptors accounted for 75.8% and 62.1% of all patients, respectively. Among 1860 female participants registered within 90 days, 218 participants died during 144,54 person-years of follow-up. More advanced stage, elevation of serum carcinoembryonic antigen and carbohydrate antigen 15-3 levels and absence of the estrogen receptor at study entry were crudely associated with an increased risk of all-cause mortality after adjustment for age. This study showed the association of several clinical characteristics with all-cause mortality in female breast cancer patients. About 1% of Japanese female breast cancer patients were diagnosed as stage IV. Invasive carcinoma was much more common than non-invasive carcinoma. Papillotubular carcinoma was the most common type of invasive carcinoma. About 75% were positive for estrogen receptor and 60% for progesterone receptor. Some characteristics would affect all-cause mortality in breast cancer patients.