Major lifestyle determinants of plasma total homocysteine distribution:: the Hordaland homocysteine study
Major lifestyle determinants of plasma total homocysteine distribution:: the Hordaland homocysteine study
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DOI：
10.1093/ajcn/67.2.263
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发表时间：
1998-02-01
影响因子：
7.1
通讯作者：
Vollset, SE
中科院分区：
文献类型：
--
作者：
Nygård, O;Refsum, H;Vollset, SE
我们报告的位置和偏度的血浆总同型半胱氨酸（tHcy）的分布，根据生活方式指数在11 941明显健康的参与者的Hordaland同型半胱氨酸研究。大多数受试者分为两个年龄组：9165例受试者年龄为40-42岁，2351例受试者年龄为65-67岁。其余425例受试者为中等年龄。在多变量分析中，性别、年龄、叶酸摄入量、吸烟状况和咖啡摄入量是tHcy浓度的最强决定因素。三个可修改因素的组合效应大于每个因素单独的效应。以低叶酸摄入、吸烟和咖啡消费为特征的生活方式与高中位tHcy浓度和明显偏高tHcy值相关。在具有相反生活方式特征的受试者中[高叶酸摄入量、不吸烟和低咖啡消费（
We report on the location and skewness of the distribution of plasma total homocysteine (tHcy) according to lifestyle indexes in 11 941 apparently healthy participants of the Hordaland Homocysteine Study. Most subjects were in two age groups: 9165 subjects were aged 40-42 y and 2351 subjects were aged 65-67 y. The remaining 425 subjects were of intermediate ages. In multivariate analysis, sex, age, folate intake, smoking status, and coffee consumption were the strongest determinants of tHcy concentration. The combined effect of the three modifiable factors was larger than the effect from each factor alone. A lifestyle profile characterized by low folate intakes, smoking, and coffee consumption was associated with a high median tHcy concentration and a pronounced skewness toward high tHcy values. In subjects characterized by a contrasting lifestyle profile [high folate intakes, nonsmoking status, and low coffee consumption (