Morphogen gradient scaling by recycling of intracellular Dpp
Morphogen gradient scaling by recycling of intracellular Dpp
复制标题
通过细胞内 Dpp 的循环利用形态发生梯度缩放
DOI：
10.1038/s41586-021-04346-w
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发表时间：
2021
期刊：
影响因子：
64.8
通讯作者：
M. Gonzalez
中科院分区：
文献类型：
--
作者：
Maria Michailidi;Zena Hadjivasiliou;Daniel Aguilar;Dimitris Basagiannis;C. Seum;M. Dubois;F. Jülicher;M. Gonzalez
形态发生梯度是建立发育组织形态模式的基础1。在发育过程中，梯度会缩放以与生长器官的大小保持成比例2,3。缩放是一种通用齿轮，可以根据生物体的大小调整模式3-8，但其机制仍不清楚。在这里，我们重点关注果蝇翼盘中的十肢麻痹 (Dpp) 梯度，揭示了缩放背后的细胞生物学基础。从小盘到大盘，Dpp 梯度的缩放是通过增加内化 Dpp 分子对 Dpp 运输的贡献来实现的：为了扩大梯度，内吞分子被重新胞吐以扩散到细胞外。为了调节组织生长过程中内吞的 Dpp 对细胞外池扩散的贡献，Dpp 结合率逐渐受到细胞外因子 Pentagone 的调节，从而驱动结垢。因此，对于某些形态发生素来说，进化可能作用于内吞运输来调节梯度的范围及其缩放，这可以使形状和模式适应不同物种的不同大小的器官。果蝇翼盘中 Dpp 梯度缩放的基础是一种涉及形态发生素 Decapentaplegic (Dpp) 细胞内循环的机制，并且该机制受到细胞外因子 Pentagone 和 Dally 的调节。
Morphogen gradients are fundamental to establish morphological patterns in developing tissues1. During development, gradients scale to remain proportional to the size of growing organs2,3. Scaling is a universal gear that adjusts patterns to size in living organisms3–8, but its mechanisms remain unclear. Here, focusing on the Decapentaplegic (Dpp) gradient in the Drosophila wing disc, we uncover a cell biological basis behind scaling. From small to large discs, scaling of the Dpp gradient is achieved by increasing the contribution of the internalized Dpp molecules to Dpp transport: to expand the gradient, endocytosed molecules are re-exocytosed to spread extracellularly. To regulate the contribution of endocytosed Dpp to the spreading extracellular pool during tissue growth, it is the Dpp binding rates that are progressively modulated by the extracellular factor Pentagone, which drives scaling. Thus, for some morphogens, evolution may act on endocytic trafficking to regulate the range of the gradient and its scaling, which could allow the adaptation of shape and pattern to different sizes of organs in different species. A mechanism involving intracellular recycling of the morphogen Decapentaplegic (Dpp) underlies the scaling of the Dpp gradient in the Drosophila wing disc, and this is modulated by the extracellular factors Pentagone and Dally.
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DOI：
10.1016/j.bbadis.2016.11.026
发表时间：
2017-02
影响因子：
6.2
作者：
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通讯作者：
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影响因子：
2.9
作者：
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DOI：
10.1042/bj20081949
发表时间：
2009-03-15
期刊：
The Biochemical journal
影响因子：
--
作者：
Shcherbo D;Murphy CS;Ermakova GV;Solovieva EA;Chepurnykh TV;Shcheglov AS;Verkhusha VV;Pletnev VZ;Hazelwood KL;Roche PM;Lukyanov S;Zaraisky AG;Davidson MW;Chudakov DM
通讯作者：
Chudakov DM
影响因子：
46.9
作者：
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通讯作者：
Knop, Michael