Nuclear Mechanisms of Insulin Resistance.
Nuclear Mechanisms of Insulin Resistance.
复制标题
DOI：
10.1016/j.tcb.2016.01.002
复制
发表时间：
2016-05
影响因子：
19
通讯作者：
Rosen ED
中科院分区：
文献类型：
--
作者：
Kang S;Tsai LT;Rosen ED
胰岛素抵抗是2型糖尿病的必要条件，并且与许多其他临床病症相关。几十年来对胰岛素抵抗机制的研究主要集中在胰岛素信号转导和其他线粒体和胞质途径的问题上。相比之下，相对较少的注意已经支付给胰岛素抵抗的转录和表观遗传的贡献者，尽管强有力的证据表明，这样的核机制发挥了重要作用，这种情况的发病机制。在这篇综述中，我们总结了胰岛素抵抗的核机制的证据，重点是三个转录因子与胰岛素在肝脏，肌肉和脂肪中的作用有重大影响。
Insulin resistance is a sine qua non of Type 2 diabetes, and is associated with many other clinical conditions. Decades of research into mechanisms underlying insulin resistance have mostly focused on problems in insulin signal transduction and other mitochondrial and cytosolic pathways. In contrast, relatively little attention has been paid to transcriptional and epigenetic contributors to insulin resistance, despite strong evidence that such nuclear mechanisms play a major role in the etiopathogenesis of this condition. In this review we summarize the evidence for nuclear mechanisms of insulin resistance, focusing on three transcription factors with a major impact on insulin action in liver, muscle, and fat.