NUDT3 rs206936 is associated with body mass index in obese Japanese women.-猫眼课题宝

DOI：

10.1507/endocrj.ej13-0100

发表时间：

2013-08

期刊：

Endocrine journal

影响因子：

通讯作者：

中科院分区：

医学4区

文献类型：

作者：

A. Kitamoto;T. Kitamoto;Seiho Mizusawa;H. Teranishi;R. So;T. Matsuo;Y. Nakata;H. Hyogo;H. Ochi;Takahiro Nakamura;S. Kamohara;N. Miyatake;K. Kotani;R. Komatsu;N. Itoh;I. Mineo;J. Wada;M. Yoneda;A. Nakajima;T. Funahashi;S. Miyazaki;K. Tokunaga;H. Masuzaki;T. Ueno;K. Chayama;K. Hamaguchi;Kentaro Yamada;T. Hanafusa;S. Oikawa;T. Sakata;Kiyoji Tanaka;Y. Matsuzawa;K. Nakao;A. Sekine;K. Hotta

代谢综合征的主要危险因素是腹内脂肪堆积，这是由腰围、腰臀比测量和内脏脂肪面积（VFA）决定的；后者可以通过计算机断层扫描 (CT) 进行精确测量。除了环境因素外，遗传因素在肥胖和脂肪分布中也发挥着重要作用。全基因组关联研究 (GWAS) 已经确定了与体重指数 (BMI) 和肥胖相关的新遗传位点。本研究利用 CT 来研究导致 BMI 较高易感性的单核苷酸多态性 (SNP) 是否与 VFA、皮下脂肪面积 (SFA) 以及 VFA 与 SFA 的比率（V/S 比率）相关。我们测量了 1424 名日本肥胖受试者（BMI ≥ 25 kg/m(2)，635 名男性和 789 名女性）的 VFA 和 SFA，这些受试者对最近 GWAS 报告的 13 个单核苷酸多态性 (SNP) 进行了基因分型，即 TNNI3K rs1514175、PTBP2 rs1555543、ADCY3 rs713586、 IRS1 rs2943650、POC5 rs2112347、NUDT3 rs206936、LINGO2 rs10968576、STK33 rs4929949、MTIF3 rs4771122、SPRY2 rs534870、MAP2K5 rs2241423、QPCTL rs2287019 和 ZC3H4 rs3810291。 NUDT3 rs206936 的 G 等位基因与日本肥胖女性的 BMI (P = 5.3 × 10(-5)) 和 SFA (P = 0.00039) 增加显着相关。经BMI调整后，未观察到rs206936与SFA之间的关联。在男性中没有观察到这种显着的关联。分析的其他 SNP 与 BMI、VFA、SFA 或 V/S 比率没有显着相关性。我们的结果表明 NUDT3 rs206936 与日本女性的 BMI 相关。

The predominant risk factor of metabolic syndrome is intra-abdominal fat accumulation, which is determined by waist circumference, waist-hip ratio measurements and visceral fat area (VFA); the latter can be accurately measured by performing computed tomography (CT). In addition to environmental factors, genetic factors play an important role in obesity and fat distribution. New genetic loci associated with body mass index (BMI) and adiposity have been identified by genome-wide association studies (GWASs). This study utilized CT to investigate whether single nucleotide polymorphisms (SNPs) that confer susceptibility to higher BMI are associated with VFA, subcutaneous fat area (SFA), and the ratio of VFA to SFA (V/S ratio). We measured the VFA and SFA of 1424 obese Japanese subjects (BMI ≥ 25 kg/m(2), 635 men and 789 women) who were genotyped for 13 single nucleotide polymorphisms (SNPs) reported by recent GWASs, namely, TNNI3K rs1514175, PTBP2 rs1555543, ADCY3 rs713586, IRS1 rs2943650, POC5 rs2112347, NUDT3 rs206936, LINGO2 rs10968576, STK33 rs4929949, MTIF3 rs4771122, SPRY2 rs534870, MAP2K5 rs2241423, QPCTL rs2287019, and ZC3H4 rs3810291. The G-allele of NUDT3 rs206936 was significantly associated with increased BMI (P = 5.3 × 10(-5)) and SFA (P = 0.00039) in the obese Japanese women. After adjustment with BMI, the association between rs206936 and SFA was not observed. This significant association was not observed in the men. The other SNPs analyzed were not significantly associated with BMI, VFA, SFA, or V/S ratio. Our results suggest that NUDT3 rs206936 is associated with BMI in Japanese women.

NUDT3 rs206936 is associated with body mass index in obese Japanese women.

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