I-2/CuCl2-promoted one-pot three-component synthesis of aliphatic or aromatic substituted 1,2,3-thiadiazoles
I-2/CuCl2-promoted one-pot three-component synthesis of aliphatic or aromatic substituted 1,2,3-thiadiazoles
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I-2/CuCl2促进脂肪族或芳香族取代1,2,3-噻二唑的一锅三组分合成
DOI：
10.1039/c9cc04254g
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发表时间：
2019
影响因子：
4.9
通讯作者：
Wu An Xin
中科院分区：
文献类型：
--
作者：
Wang Can;Geng Xiao;Zhao Peng;Zhou You;Wu Yan Dong;Cui Yan Fang;Wu An Xin
研究了一种由脂肪族或芳香族取代的甲基酮、对甲苯磺酰肼和硫氰酸钾合成1，2，3-噻二唑的I_2/CuCl_2促进的“一锅法”三组分策略。简单的和商业上可获得的起始材料，广泛的底物范围，和优异的官能团耐受性，使这种策略的应用实际。此外，以硫氰酸钾为无臭硫源，实现了1，2，3-噻二唑的合成。
An efficient I2/CuCl2-promoted one-pot three-component strategy for the construction of 1,2,3-thiadiazoles from aliphatic- or aromatic-substituted methyl ketones, p-toluenesulfonyl hydrazide, and potassium thiocyanate has been developed. Simple and commercially available starting materials, a broad substrate scope, and excellent functional group tolerability make this strategy practical for applications. Furthermore, 1,2,3-thiadiazole synthesis was realized by using potassium thiocyanate as an odorless sulfur source.