VIRULENCE FACTORS OF CRYPTOCOCCUS-NEOFORMANS
VIRULENCE FACTORS OF CRYPTOCOCCUS-NEOFORMANS
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DOI：
10.1016/s0966-842x(00)88957-x
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发表时间：
1995-08-01
影响因子：
15.9
通讯作者：
KOZEL, TR
中科院分区：
文献类型：
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作者：
KOZEL, TR
隐球菌病是一种严重的真菌病，患者患有艾滋病或其他T细胞介导的宿主防御缺陷。新生隐球菌会产生几种毒力因子，最著名的是多糖壳和酚氧化酶。对隐球菌毒力因子的分子研究有助于我们理解这种酵母的病理生物学，并将使我们能够识别抗真菌治疗的新靶点。
Cryptococcosis is a serious fungal disease in patients with AIDS or other defects in T-cell-mediated host defenses.Cryptococcus neoformans produces several virulence factors, most notably the polysaccharide capsule and phenol oxidase. Molecular studies of cryptococcal virulence factors have contributed to our understanding of the pathobiology of this yeast, and will enable the identification of new targets for antifungal therapy.