Heritabilities of apolipoprotein and lipid levels in three countries
Heritabilities of apolipoprotein and lipid levels in three countries
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DOI：
10.1375/1369052022956
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发表时间：
2002-04-01
期刊：
影响因子：
--
通讯作者：
Boomsma, DI
中科院分区：
文献类型：
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作者：
Beekman, M;Heijmans, BT;Boomsma, DI
本研究探讨了基因和环境对心血管疾病途径中重要的中间表型载脂蛋白和脂质水平变化的影响。遗传力估计，包括载脂蛋白E和所有的水平，以前很少报道。我们研究了来自荷兰（两个队列; n = 160对，年龄13-22岁和n = 204对，年龄34-62岁），澳大利亚（n = 1362对，年龄28-92岁）和瑞典（n = 302对，年龄42-88岁）的双胞胎样本。双生子样本中载脂蛋白和血脂水平的变化主要取决于加性遗传因素的影响。没有明显的证据表明共同环境的影响。在任何样本中，均未观察到任何表型的遗传力估计值存在性别差异。遗传力范围为0.48-0.87，大多数遗传力超过0.60。荷兰样本的遗传力估计值显著高于澳大利亚样本。瑞典人的遗传力介于荷兰人和澳大利亚人之间，与其他两个样本的遗传力没有显著差异。虽然样本的具体影响是存在的，我们已经表明，基因在确定载脂蛋白和脂质水平的方差在四个独立的双胞胎样本从三个不同的国家发挥了重要作用。
This study investigated the influence of genes and environment on the variation of apolipoprotein and lipid levels, which are important intermediate phenotypes in the pathways toward cardiovascular disease. Heritability estimates are presented, including those for apolipoprotein E and All levels which have rarely been reported before. We studied twin samples from the Netherlands (two cohorts; n = 160 pairs, aged 13-22 and n = 204 pairs, aged 34-62), Australia (n = 1362 pairs, aged 28-92) and Sweden (n = 302 pairs, aged 42-88). The variation of apolipoprotein and lipid levels depended largely on the influences of additive genetic factors in each twin sample. There was no significant evidence for the influence of common environment. No sex differences in heritability estimates for any phenotype in any of the samples were observed. Heritabilities ranged from 0.48-0.87, with most heritabilities exceeding 0.60. The heritability estimates in the Dutch samples were significantly higher than in the Australian sample. The heritabilities for the Swedish were intermediate to the Dutch and the Australian samples and not significantly different from the heritabilities in these other two samples. Although sample specific effects are present, we have shown that genes play a major role in determining the variance of apolipoprotein and lipid levels in four independent twin samples from three different countries.