Metformin and Its Immune-Mediated Effects in Various Diseases.
Metformin and Its Immune-Mediated Effects in Various Diseases.
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DOI：
10.3390/ijms24010755
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发表时间：
2023-01-01
影响因子：
5.6
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中科院分区：
文献类型：
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二甲双胍一直是治疗2型糖尿病（T2 D）的长期处方药，其对病毒感染、自身免疫性疾病、衰老和癌症的有益作用也得到了认可。Metalloprotein调节各种免疫介导的细胞如CD 4+和CD+8 T细胞的分化和活化。腺苷5′-磷酸活化蛋白激酶（AMPK）和哺乳动物雷帕霉素靶蛋白复合物1（mTORC 1）通路的激活可能参与了这一过程。最近使用细胞外通量分析仪的研究表明，二甲双胍改变了糖酵解、氧化磷酸化（OXPHOS）、脂质氧化和β-氨基分解的活性，这些活性与各种疾病状态（如病毒感染、自身免疫性疾病、衰老和癌症）中CD 4+和CD+8 T细胞中细胞因子产生的调节密切相关。
Metformin has been a long-standing prescribed drug for treatment of type 2 diabetes (T2D) and its beneficial effects on virus infection, autoimmune diseases, aging and cancers are also recognized. Metformin modulates the differentiation and activation of various immune-mediated cells such as CD4+ and CD+8 T cells. The activation of adenosine 5′-monophosphate-activated protein kinase (AMPK) and mammalian target of rapamycin complex 1 (mTORC1) pathway may be involved in this process. Recent studies using Extracellular Flux Analyzer demonstrated that metformin alters the activities of glycolysis, oxidative phosphorylation (OXPHOS), lipid oxidation, and glutaminolysis, which tightly link to the modulation of cytokine production in CD4+ and CD+8 T cells in various disease states, such as virus infection, autoimmune diseases, aging and cancers.