Dipeptidyl peptidase I cleaves matrix-associated proteins and is expressed mainly by mast cells in normal dog airways.
Dipeptidyl peptidase I cleaves matrix-associated proteins and is expressed mainly by mast cells in normal dog airways.
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二肽基肽酶 I 裂解基质相关蛋白，主要由正常狗气道中的肥大细胞表达。
DOI：
10.1165/ajrcmb.22.2.3767
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发表时间：
2000
影响因子：
6.4
通讯作者：
Caughey,GH
中科院分区：
文献类型：
--
作者：
Wolters,PJ;Laig-Webster,M;Caughey,GH
Dipeptidyl peptidase I (DPPI) is a cysteine protease found in many tissues, including the lung. Major cell types expressing DPPIin vitroinclude myelomonocytic cells, cytotoxic T cells, and mast cells. After activation and degranulation, cytotoxic T cells and mast cells secrete DPPI. With a goal of clarifying possible roles for DPPI in lung diseases, we sought to identify cells expressing DPPI in lung tissue, hypothesizing that lung mast cells are major producers of DPPI and that secreted DPPI cleaves extracellular matrix proteins. To address these hypotheses, we used immunohistochemical techniques to localize DPPI in normal dog airways, lung, and cultured mast cells, and we used purified DPPI to examine cleavage of matrix-associated proteinsin vitro. We found that mast cells are the major identifiable source of DPPI in airways and that macrophages are the major source in alveoli. Within mast cells, DPPI localizes to cytoplasmic granules. We also found that DPPI endoproteolytically cleaves the extracellular matrix proteins fibronectin and collagen types I, III, and IV. The finding of DPPI in airway mast cells and its cleavage of matrix proteins suggest the possibility that DPPI plays a role in mast cell–mediated turnover of matrix proteins and in airway remodeling of chronic airway diseases such as asthma.
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DOI：
--
发表时间：
1977
期刊：
Acta biologica et medica Germanica
影响因子：
--
作者：
H. Kirschke;J. Langner;B. Wiederanders;S. Ansorge;P. Bohley;H. Hanson
通讯作者：
H. Kirschke;J. Langner;B. Wiederanders;S. Ansorge;P. Bohley;H. Hanson
二肽基肽酶 I 的选择性抑制剂会损害 CD8 T 细胞细胞毒效应功能的产生。
DOI：
--
发表时间：
1997
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Thiele,DL;McGuire,MJ;Lipsky,PE
通讯作者：
Lipsky,PE
二肽基肽酶 I 富含体外和体内激活的细胞毒性 T 淋巴细胞颗粒。
DOI：
--
发表时间：
1993
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Brown,GR;McGuire,MJ;Thiele,DL
通讯作者：
Thiele,DL
影响因子：
4.8
作者：
DOLENC, I;TURK, B;TURK, V
通讯作者：
TURK, V
影响因子：
37.8
作者：
Frangogiannis, NG;Lindsey, ML;Entman, ML
通讯作者：
Entman, ML