Use of multi-coil parallel-gap resonators for co-registration EPR/NMR imaging
Use of multi-coil parallel-gap resonators for co-registration EPR/NMR imaging
复制标题
DOI：
10.1016/j.jmr.2006.09.014
复制
发表时间：
2007-01-01
影响因子：
2.2
通讯作者：
Fujii, Hirodata
中科院分区：
文献类型：
--
作者：
Kawada, Yuuki;Hirata, Hiroshi;Fujii, Hirodata
本文报道了使用RF谐振器进行连续波电子顺磁共振（cw-EPR）和质子核磁共振（NMR）成像的实验研究。我们开发了一种复合谐振器系统与多线圈平行间隙共振器共配准EPR/NMR成像。每个谐振器的谐振频率对于NMR为21.8MHz，对于EPR为670MHz。将用于EPR的较小谐振器（直径22 mm）同轴地放置在用于NMR的较大谐振器（直径40 mm）中。复合谐振器系统中的RF磁场通过测量试管中的均匀4-羟基-2，2，6，6-四甲基-哌啶基氧基（4-羟基-TEMPO）溶液来可视化。还测量了含有蒸馏水和4-羟基-TEMPO溶液的五个管的体模，以证明这种复合谐振器系统在生物医学科学中的潜在用途。在三个管中获得了4-羟基-TEMPO的未成对电子图像，并成功地映射到五个管的质子图像上。复合谐振器系统的实施中的技术问题进行了讨论，关于共配准EPR/NMR成像的动物实验。(c)2006年爱思唯尔公司All rights reserved.
This article reports experimental investigations on the use of RF resonators for continuous-wave electron paramagnetic resonance (cw-EPR) and proton nuclear magnetic resonance (NMR) imaging. We developed a composite resonator system with multi-coil parallel-gap resonators for co-registration EPR/NMR imaging. The resonance frequencies of each resonator were 21.8 MHz for NMR and 670 MHz for EPR. A smaller resonator (22 mm in diameter) for use in EPR was placed coaxially in a larger resonator (40 mm in diameter) for use in NMR. RF magnetic fields in the composite resonator system were visualized by measuring a homogeneous 4-hydroxy-2,2,6,6-tetramethyl-piperidinooxy (4-hydroxy-TEMPO) solution in a test tube. A phantom of five tubes containing distilled water and 4-hydroxy-TEMPO solution was also measured to demonstrate the potential usefulness of this composite resonator system ill biomedical science. An image of unpaired electrons was obtained for 4-hydroxy-TEMPO in three tubes, and was successfully mapped oil the proton image for five tubes. Technical problems in the implementation of a composite resonator system are discussed with regard to co-registration EPR/NMR imaging for animal experiments. (c) 2006 Elsevier Inc. All rights reserved.