The Newcastle 85+ study: biological, clinical and psychosocial factors associated with healthy ageing: study protocol.
The Newcastle 85+ study: biological, clinical and psychosocial factors associated with healthy ageing: study protocol.
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DOI：
10.1186/1471-2318-7-14
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发表时间：
2007-06-26
期刊：
影响因子：
4.1
通讯作者：
Kirkwood T
中科院分区：
文献类型：
--
作者：
Collerton J;Barrass K;Bond J;Eccles M;Jagger C;James O;Martin-Ruiz C;Robinson L;von Zglinicki T;Kirkwood T
与其他发达国家一样，英国人口的年龄结构正在发生显著变化，其特点是预期寿命不断延长，老年人口比例持续增长。关于年龄最大的老年人（85岁以上）的健康状况的最新信息非常少，而他们是人口中增长最快的部分。有必要从政策和科学的角度详细描述这一群体的健康状况以及影响个人健康轨迹的因素。对于很大一部分医疗状况，年龄是最大的单一风险因素。获得关于为什么衰老细胞和组织更容易受到病理学影响的新知识可能会催化激进的新见解和干预机会。纽卡斯尔85岁以上研究的目的是揭示800名85岁以上老年人的初始队列中的健康谱;随着队列年龄的增长，检查健康轨迹和结果及其与潜在生物，医学和社会因素的关联;并促进对衰老生物学性质的理解。来自纽卡斯尔和北泰恩赛德的800名85岁的老年人将在基线时招募，并随访至最后一名参与者死亡。符合条件的个人将是所有在2006年年满85岁（即1921年出生）并在纽卡斯尔或北泰恩赛德全科诊所注册的人。在基线、18个月和36个月时，研究护士将在受试者目前的住所（自己的家或机构）对受试者进行访视。评估程序包括详细的多层面健康评估，以及审查全科医疗记录。参与者将被标记与NHS中央登记，以提供详细的日期和死亡原因。纽卡斯尔85岁以上研究将解决85岁以上人口的健康和健康维护的关键问题，特别关注健康变化因素的定量评估，以及健康，营养和衰老基本过程的生物标志物之间的关系。
The UK, like other developed countries, is experiencing a marked change in the age structure of its population characterised by increasing life expectancy and continuing growth in the older fraction of the population. There is remarkably little up-to-date information about the health of the oldest old (over 85 years), demographically the fastest growing section of the population. There is a need, from both a policy and scientific perspective, to describe in detail the health status of this population and the factors that influence individual health trajectories. For a very large proportion of medical conditions, age is the single largest risk factor. Gaining new knowledge about why aged cells and tissues are more vulnerable to pathology is likely to catalyse radical new insights and opportunities to intervene. The aims of the Newcastle 85+ Study are to expose the spectrum of health within an inception cohort of 800 85 year-olds; to examine health trajectories and outcomes as the cohort ages and their associations with underlying biological, medical and social factors; and to advance understanding of the biological nature of ageing. A cohort of 800 85 year olds from Newcastle and North Tyneside will be recruited at baseline and followed until the last participant has died. Eligible individuals will be all those who turn 85 during the year 2006 (i.e. born in 1921) and who are registered with a Newcastle or North Tyneside general practice. Participants will be visited in their current residence (own home or institution) by a research nurse at baseline, 18 months and 36 months. The assessment protocol entails a detailed multi-dimensional health assessment together with review of general practice medical records. Participants will be flagged with the NHS Central Register to provide details of the date and cause of death. The Newcastle 85+ Study will address key questions about health and health-maintenance in the 85+ population, with a particular focus on quantitative assessment of factors underlying variability in health, and on the relationships between health, nutrition and biological markers of the fundamental processes of ageing.