Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway
Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway
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DOI：
10.1101/gad.12.6.770
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发表时间：
1998-03-15
影响因子：
10.5
通讯作者：
Taniguchi, T
中科院分区：
文献类型：
--
作者：
Miyazaki, T;Takaoka, A;Taniguchi, T
许多细胞因子通过激活受体相关的Janus家族蛋白酪氨酸激酶（Jak PTKs）将信号传递到细胞内部。白细胞介素-2受体（IL-2R）与Jak1和Jak3 ptk相关，这些ptk的配体诱导活化对淋巴细胞增殖至关重要。在这里，非受体PTK， Pyk2，被发现在IL-2刺激后以jak依赖的方式被激活。此外，内源性Pyk2和Jak3之间存在物理关联，Pyk2的显性干扰突变体抑制il -2诱导的细胞增殖，而不影响Stat5的激活。总之，这些结果表明Pyk2是jak介导的IL-2信号通路的一个新发现的成分。
Many cytokines transmit signals to the cell interior through activation of receptor-associated, Janus family protein tyrosine kinases (Jak PTKs). The interleukin-2 receptor (IL-2R) is associated with the Jak1 and Jak3 PTKs, and ligand-induced activation of these PTKs is essential for lymphocyte proliferation. Here, the nonreceptor PTK, Pyk2, was found to be activated following IL-2 stimulation in a Jak-dependent manner. Furthermore, physical association was detected between endogenous Pyk2 and Jak3, and a dominant interfering mutant of Pyk2 inhibited IL-2-induced cell proliferation without affecting Stat5 activation. Collectively, these results suggest that Pyk2 is a newly identified component of the Jak-mediated IL-2 signaling pathway.