Sheet conductor model of brain slices for stimulation and recording with planar electronic contacts
Sheet conductor model of brain slices for stimulation and recording with planar electronic contacts
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DOI：
10.1007/s00249-002-0213-7
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发表时间：
2002-06-01
影响因子：
2
通讯作者：
Fromherz, P
中科院分区：
文献类型：
--
作者：
Fromherz, P
考虑到电解液表面和电子导体衬底的边界条件，考虑了脑切片中的电流和电压。介绍了一种考虑槽体欧姆漏导和基片电容耦合的片状导体模型。它将神经元活动的电流源密度分配给平面接触记录的细胞外场电位，并将平面电容接触的电流与引发神经元活动的场电位联系起来。两个例子被解析解决了：通过分层大脑切片的记录和圆形电极的刺激。这项研究为在微电子芯片上进行脑切片或视网膜的神经物理实验奠定了基础。
Current and voltage in a brain slice are considered, taking into account the boundary conditions at the surface to an electrolyte bath and at the substrate of an electron conductor. A sheet conductor model is introduced with ohmic leak conductance to the bath and capacitive coupling to the substrate. It assigns a current-source density of neuronal activity to extracellular field potentials recorded by planar contacts, and it relates the current of planar capacitive contacts to the field potential that elicits neuronal activity. Two examples are analytically solved: the recording across a layered brain slice and the stimulation by a circular electrode. The study forms the basis for neurophysical experiments with brain slices or retinae on microelectronic chips.