Small-molecule-based human genome G4 profiling reveals potential gene regulation activity
Small-molecule-based human genome G4 profiling reveals potential gene regulation activity
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基于小分子的人类基因组 G4 分析揭示了潜在的基因调控活性
DOI：
10.1039/c8cc10052g
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发表时间：
2019
影响因子：
4.9
通讯作者：
Zhou Xiang
中科院分区：
文献类型：
--
作者：
Zeng Weiwu;Wu Fan;Liu Chaoxing;Yang Yan;Wang Bingyao;Yuan Yushu;Wang Jiaqi;Chen Yuqi;Fu Boshi;Wu Zhiguo;Zhou Xiang
基于小分子的G4从基因组中分离，已经能够识别总共51个 446个PQS(潜在的G-四链位点)。PDP与细胞孵育3h~72h后，多种基因的差异表达，提示G4S具有潜在的基因调控功能。
Small-molecule-based G4 isolation from genomic DNA has enabled the identification of a total of 51 446 PQSs (potential G-quadruplex sites). Incubating cells with PDP for 3 h to 72 h resulted in the differential expression of a variety of genes, indicating a potential function of G4s in gene regulation.