Visual imaging as a predictor of neurodegeneration in experimental autoimmune demyelination and multiple sclerosis.
Visual imaging as a predictor of neurodegeneration in experimental autoimmune demyelination and multiple sclerosis.
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DOI：
10.1186/s40478-022-01391-y
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发表时间：
2022-06-15
影响因子：
7.1
通讯作者：
中科院分区：
文献类型：
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作者：
Thalamic volume is associated with clinical disability in multiple sclerosis (MS) and is vulnerable to secondary neurodegeneration due to its extensive connectivity throughout the central nervous system (CNS). Using a model of autoimmune demyelination that exhibits CNS-infiltrating immune cells in both spinal cord white matter and optic nerve, we sought to evaluate neurodegenerative changes due to lesions affecting the spino- and retino-thalamic pathways. We found comparable axonal loss in spinal cord white matter and optic nerve during the acute phase of disease consistent with synaptic loss, but not neuronal cell body loss in the thalamic nuclei that receive input from these discrete pathways. Loss of spinal cord neurons or retinal ganglion cells retrograde to their respective axons was not observed until the chronic phase of disease, where optical coherence tomography (OCT) documented reduced inner retinal thickness. In patients with relapsing–remitting MS without a history of optic neuritis, OCT measures of inner retinal volume correlated with retino-thalamic (lateral geniculate nucleus) and spino-thalamic (ventral posterior nucleus) volume as well as neuroperformance measures. These data suggest retinal imaging may serve as an important noninvasive predictor of neurodegeneration in MS. The online version contains supplementary material available at 10.1186/s40478-022-01391-y.
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DOI：
10.4049/jimmunol.1501097
发表时间：
2015-09-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Carbajal KS;Mironova Y;Ulrich-Lewis JT;Kulkarni D;Grifka-Walk HM;Huber AK;Shrager P;Giger RJ;Segal BM
通讯作者：
Segal BM
影响因子：
11.2
作者：
Bischof A;Papinutto N;Keshavan A;Rajesh A;Kirkish G;Zhang X;Mallott JM;Asteggiano C;Sacco S;Gundel TJ;Zhao C;Stern WA;Caverzasi E;Zhou Y;Gomez R;Ragan NR;Santaniello A;Zhu AH;Juwono J;Bevan CJ;Bove RM;Crabtree E;Gelfand JM;Goodin DS;Graves JS;Green AJ;Oksenberg JR;Waubant E;Wilson MR;Zamvil SS;University of California, San Francisco MS-EPIC Team;Cree BAC;Hauser SL;Henry RG
通讯作者：
Henry RG
影响因子：
13.6
作者：
Evonuk, Kirsten S.;Doyle, Ryan E.;DeSilva, Tara M.
通讯作者：
DeSilva, Tara M.
DOI：
10.1177/2055217319827618
发表时间：
2019-01-01
影响因子：
2.8
作者：
Kletenik, Isaiah;Alvarez, Enrique;Medina, Luis D.
通讯作者：
Medina, Luis D.
DOI：
10.3791/54348
发表时间：
2016-09-12
期刊：
Journal of visualized experiments : JoVE
影响因子：
--
作者：
Evonuk KS;Moseley CE;Doyle RE;Weaver CT;DeSilva TM
通讯作者：
DeSilva TM