Phenotypical characteristics of undifferentiated carcinoma of the pancreas: a comparison with pancreatic ductal adenocarcinoma and relevance of E-cadherin, alpha catenin and beta catenin expression.
Phenotypical characteristics of undifferentiated carcinoma of the pancreas: a comparison with pancreatic ductal adenocarcinoma and relevance of E-cadherin, alpha catenin and beta catenin expression.
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胰腺未分化癌的表型特征：与胰腺导管腺癌的比较以及 E-钙粘蛋白、α 连环蛋白和 β 连环蛋白表达的相关性。
DOI：
10.3892/or.8.4.745
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发表时间：
2001
期刊：
影响因子：
4.2
通讯作者：
M. Tsuneyoshi
中科院分区：
文献类型：
--
作者：
H. Yonemasu;M. Takashima;K. Nishiyama;T. Ueki;Takashi Yao;Masao Tanaka;M. Tsuneyoshi
本文分析了胰腺未分化癌（UC）的特点，并与低分化腺癌（PA）进行了比较。本文对8例胰腺UC进行了临床病理和免疫组化观察，并与20例PA进行了比较。UC的肿瘤体积大、局部浸润和淋巴结转移多见，与PA相比，UC的预后明显较差（p=0.022）。免疫组化，E-钙粘蛋白表达完全丢失7/8 UC的情况下，而一半的PA的情况下，显示了强烈的反应性E-钙粘蛋白。与PA相比，UC中α-和β-连环蛋白表达倾向于受损。结果表明，粘附分子的表达改变与去分化的变化，是其侵略性的生物学行为的贡献。
The characteristics of undifferentiated (anaplastic) carcinoma (UC) of the pancreas were analysed and compared with those of poorly differentiated adenocarcinoma (PA). Eight cases of UC of the pancreas were evaluated by clinicopathological and immunohistochemical methods and compared with 20 cases of PA. Large size of the tumor, local invasion and lymph node metastasis were frequently seen in UC, leading to a significantly worse prognosis compared to that of PA (p=0.022). Immunohistochemically, E-cadherin expression was completely lost in 7/8 UC cases, whereas half the PA cases revealed a strong reactivity for E-cadherin. alpha- and beta-catenin expressions tended to be impaired in UC compared with PA. The results suggest that the altered expression of adhesion molecules is correlated with dedifferentiated change and is contributory to its aggressive biological behaviour.