Trypanocidal Terpenoids from Laurus nobilis
Trypanocidal Terpenoids from Laurus nobilis
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来自月桂树的杀锥虫萜类化合物
DOI：
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
T. Aoki
中科院分区：
文献类型：
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作者：
N. Uchiyama;K. Matsunaga;F. Kiuchi;G. Honda;Akiko Tsubouchi;J. Nakajima;T. Aoki
幽灵病是查加斯病的病原，在中南美洲流行。在亚洲药用植物杀锥虫活性筛选工作中，樟科樟树干叶提取物具有较强的杀锥虫活性。月桂的叶子被用作香料，被称为月桂叶或月桂叶。它们也被用作治疗风湿病和疮疮的民间药物。虽然已有报道能抑制乙醇负荷大鼠血液中乙醇含量的升高，抑制脂多糖激活的小鼠腹腔巨噬细胞一氧化氮的产生，诱导谷胱甘肽转移酶活性，以及杀线虫活性等生物活性，但有关该植物抗原虫活性的研究尚未见报道。在此，我们报道了诺比利乳杆菌杀锥虫活性成分的分离和鉴定。
phoria, is the etiologic agent of Chagas’ disease which is endemic in Central and South America. In our screening work on medicinal plants used in Asian counties for trypanocidal activity, extracts of the dried leaves of Laurus nobilis L. (Lauraceae) showed strong trypanocidal activity against epimastigotes of T. cruzi. Leaves of L. nobilis are used as a spice known as laurel or bay leaf. They are also used as a folk medicine for rheumatism and scabies. Although some biological activities such as inhibition of elevation of blood ethanol level in ethanol-loaded rat, inhibition of nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophages, induction of glutathione Stransferase activity, and nematocidal activity were reported for the constituents of L. nobilis, nothing has been reported on anti-protozoan constituents of this plant. Here, we report the isolation and identification of trypanocidal constituents of L. nobilis.