NERVE GROWTH-FACTOR IN MOUSE SERUM AND SALIVA - ROLE OF SUBMANDIBULAR-GLAND
NERVE GROWTH-FACTOR IN MOUSE SERUM AND SALIVA - ROLE OF SUBMANDIBULAR-GLAND
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DOI：
10.1073/pnas.74.6.2330
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发表时间：
1977-01-01
影响因子：
11.1
通讯作者：
YOUNG, M
中科院分区：
文献类型：
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作者：
MURPHY, RA;SAIDE, JD;YOUNG, M
重新审视了小鼠唾液腺是神经生长因子（NGF）分泌的内分泌器官的概念。用放射免疫法测定了雄性和雌性小鼠以及去除下颌腺的小鼠的血清蛋白浓度。尽管雄性小鼠的下颌骨腺比雌性小鼠含有更多的NGF，但在循环浓度方面没有发现性别差异。在颌下腺切除或给药几种自主神经激动剂后，血清NGF浓度没有变化。就神经生长因子而言，下颌腺不是内分泌器官。另一方面，小鼠唾液中通常会分泌高浓度的NGF，其水平反映了腺体中存在的NGF量的性别差异。这一发现表明唾液腺是NGF的外分泌器官，该蛋白可能在唾液中发挥生物学作用。
The concept that the salivary gland of the mouse is an endocrine organ for nerve growth factor (NGF) was reexamined. Serum concentrations of the protein were measured by radioimmunoassay in male and female mice and in mice from which the submandibular glands were removed. In spite of the fact that the submandibular glands of male mice contained more NGF than did those of female mice, no sex differences in circulating concentrations of the factor were detected. Serum concentrations of NGF did not change after submandibular gland removal or after administration of several autonomic agonists. The submandibular glands are not endocrine organs with respect to NGF. On the other hand, extremely high concentrations of the factor are normally secreted in mouse saliva at levels that reflect the sex differences in the amount of NGF present in the glands. This finding suggests that the salivary gland is an exocrine organ for NGF and that the protein may play a biological role in saliva.