Global associations between copy number and transcript mRNA microarray data: an empirical study.
Global associations between copy number and transcript mRNA microarray data: an empirical study.
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随着越来越多的癌症分析研究同时测定转录物mRNA和拷贝数表达水平，一个自然的问题涉及跨两种类型的基因组数据联合收割机信息的潜力。在这篇文章中，我们进行了一项研究，以评估在几个实验中两种类型的数据之间的关联的性质。我们报告了几个有趣的发现：1）基因表达和拷贝数之间的整体相关性相对较弱，但在研究中是一致的; 2）有强有力的证据表明拷贝数对基因表达的顺式剂量效应; 3）分割拷贝数水平有助于提高相关性。
With an increasing number of cancer profiling studies assaying both transcript mRNA and copy number expression levels, a natural question then involves the potential to combine information across the two types of genomic data. In this article, we perform a study to assess the nature of association between the two types of data across several experiments. We report on several interesting findings: 1) global correlation between gene expression and copy number is relatively weak but consistent across studies; 2) there is strong evidence for a cis-dosage effect of copy number on gene expression; 3) segmenting the copy number levels helps to improve correlations.