Interaction of vagal lung afferents with inhalation of histamine aerosol in anesthetized dogs.
Interaction of vagal lung afferents with inhalation of histamine aerosol in anesthetized dogs.
复制标题
迷走神经肺传入与麻醉狗吸入组胺气溶胶的相互作用。
作者：
Schelegle,ES;Mansoor,JK;Green,JF
在 7 只 α-氯醛糖麻醉的狗中，我们检查了肺传入神经对吸入 10 次组胺气溶胶引起的快速、浅呼吸的影响。在四只自主呼吸的狗中，吸入组胺导致呼吸频率增加、潮气量减少和动态肺顺应性降低。选择性阻断肺 C 纤维消除了反射引起的呼吸频率增加，但没有显着影响潮气量或肺顺应性的减少。特布他林联合 C 纤维阻断治疗消除了组胺引起的潮气量和肺顺应性的减少。在三只单独的α-氯醛糖麻醉、开胸、机械通气的狗中，我们记录到吸入组胺气溶胶引起的快速适应肺牵张受体（RAR）的吸气活动增加。选择性 C 纤维阻断消除了组胺诱导的 RAR 活性增加，同时仅部分减弱了肺顺应性的降低。我们得出的结论是，组胺诱导的 RAR 活性增加取决于完整的 C 纤维，而不是组胺对 RAR 的直接影响或组胺降低肺顺应性的间接影响。此外，我们的数据说明了各种迷走神经传入之间发生的多重相互作用及其在组胺吸入诱导的反射中的作用。
In seven alpha-chloralose anesthetized dogs we examined the contribution of lung afferents to the rapid, shallow breathing induced by inhalation of 10 breaths of histamine aerosol. In four spontaneously breathing dogs, the inhalation of histamine caused an increased respiratory frequency, decreased tidal volume, and decreased dynamic lung compliance. Selective blockade of pulmonary C-fibers abolished a reflex-induced increase in respiratory frequency but did not significantly affect the reductions in tidal volume or lung compliance. Terbutaline treatment in combination with C-fiber blockade abolished the reductions in tidal volume and lung compliance induced by histamine. In three separate alpha-chloralose anesthetized, open-chest, mechanically ventilated dogs, we recorded an increase in the inspiratory activity of rapidly adapting pulmonary stretch receptors (RARs) induced by the inhalation of histamine aerosol. Selective C-fiber blockade abolished histamine-induced increases in RAR activity while only partially attenuating reductions in lung compliance. We conclude that the increase in RAR activity induced by histamine depends on intact C-fibers and not on a direct effect of histamine on RARs or an indirect effect of histamine reducing lung compliance. In addition, our data illustrate the multiple interactions that occur between the various vagal afferents and their roles in the reflexes induced by histamine inhalation.