Recognizing and reversing the immunosuppressive tumor microenvironment of head and neck cancer
Recognizing and reversing the immunosuppressive tumor microenvironment of head and neck cancer
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DOI：
10.1007/s12026-012-8306-6
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发表时间：
2012-12-01
影响因子：
4.4
通讯作者：
Sikora, Andrew G.
中科院分区：
文献类型：
--
作者：
Tong, Charles C. L.;Kao, Johnny;Sikora, Andrew G.
据估计，美国口腔和咽癌的年发病率为3.9万例，全球为26万例。尽管在手术、化疗和放射治疗方面取得了重大进展，但局部晚期头颈部肿瘤的5年存活率仍保持在50%。随着现有治疗的进一步加强，多模式治疗的发病率已经很高，显然需要新的治疗策略[1]。越来越多的证据表明，头颈部鳞状细胞癌(HNSCC)的肿瘤微环境是高度免疫抑制的，由可溶性和细胞相关的抑制介质和宿主免疫抑制细胞的募集介导。因此，了解和逆转HNSCC中肿瘤介导的免疫抑制的特定机制是产生有效的抗肿瘤免疫反应的重要途径，无论是作为基于免疫的治疗的组成部分还是作为传统治疗方法的补充。本文概述了HNSCC肿瘤微环境中重要的免疫抑制机制以及增强抗肿瘤免疫反应的潜在途径。
The estimated annual incidence of oral cavity and pharyngeal cancer is 39,000 in the United States and 260,000 cases worldwide. Despite significant advances in surgery, chemotherapy and radiotherapy, the 5-year survival rate for locally advanced head and neck tumors remains at 50 %. With further intensification of existing treatment limited by the already significant morbidity of multi-modality treatment, there is a clear need for novel therapeutic strategies [1]. Accumulating evidence suggests that the tumor microenvironment of head and neck squamous cell carcinoma (HNSCC) is highly immunosuppressive, mediated by soluble and cell-associated inhibitory mediators and recruitment of host immunosuppressive cells. Thus, understanding and reversing the specific mechanisms underlying tumor-mediated immunosuppression in HNSCC is an important approach to generating an effective antitumor immune response, either as a component of immune-based therapy or as a complement to conventional treatment approaches. This article outlines significant immune-suppressive mechanisms in the HNSCC tumor microenvironment and potential approaches to enhancing the antitumor immune response.