Different effects of ERβ and TROP2 expression in Chinese patients with early-stage colon cancer
Different effects of ERβ and TROP2 expression in Chinese patients with early-stage colon cancer
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ERβ和TROP2表达对中国早期结肠癌患者的不同影响
DOI：
10.1007/s13277-012-0484-2
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发表时间：
2012-12-01
期刊：
影响因子：
--
通讯作者：
Wan, De-Sen
中科院分区：
文献类型：
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作者：
Fang, Yu-Jing;Wang, Guo-Qiang;Wan, De-Sen
雌激素受体 β (ER β) 和 TROP2 在结肠癌中表达，并可能在其中发挥重要作用。我们探讨了ERβ和TROP2表达与早期结肠癌预后的关系。采用免疫组化法检测中山大学肿瘤防治中心1995年至2003年间接受根治性手术切除的220例中国T3N0M0（IIa期）和T4N0M0（IIb期）结肠癌患者正常粘膜和肿瘤组织中ERβ和TROP2的水平。采用Cox比例风险回归模型分析总生存期（OS） 采用ROC曲线、Kaplan-Meier估计、对数秩检验和Jackknife法显示ERβ和TROP2表达在癌症不同阶段的影响。 IIa 期和 IIb 期结肠癌患者的 5 年生存率没有显着差异（分别为 83% 和 80%）。 ERβ的高表达与IIa期和IIb期结肠癌的OS降低相关，而TROP2的高表达与IIb期结肠癌的OS降低相关。 ERβ和TROP2的表达分别在IIa期和IIb期结肠癌中具有抑癌和促癌作用。
Estrogen receptor beta (ER beta) and TROP2 expressed in colon carcinoma and might play an important role there. We explored the relationship of ER beta and TROP2 expression with the prognosis of early-stage colon cancer. ER beta and TROP2 levels were assessed by immunohistochemistry in normal mucosa and tumoral tissues from 220 Chinese patients with T3N0M0 (stage IIa) and T4N0M0 (stage IIb) colon cancer in the Cancer Center, Sun Yat-sen University, who underwent curative surgical resection between 1995 and 2003. The Cox proportional hazards regression model was applied to analyze the overall survival (OS) data, and the ROC curve, Kaplan-Meier estimate, log rank test, and Jackknife method were used to show the effect of ER beta and TROP2 expression at different stages of cancer. The 5-year survival rates were not significantly different between the patients with stage IIa and stage IIb colon cancer (83 vs. 80 %, respectively). The high expression of ER beta was related to decreasing OS in stage IIa and stage IIb colon cancer, while the high expression of TROP2 was related to decreasing OS in stage IIb colon cancer. The expression of ER beta and TROP2 has tumor-suppressive and tumor-promoting effect in stage IIa and stage IIb colon cancer, respectively.