Prevention from hypoxia-induced apoptosis by pre-conditioning:: a mechanistic approach in cultured neurons from fetal rat forebrain
Prevention from hypoxia-induced apoptosis by pre-conditioning:: a mechanistic approach in cultured neurons from fetal rat forebrain
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DOI：
10.1016/s0169-328x(98)00123-5
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发表时间：
1998-07-15
期刊：
影响因子：
--
通讯作者：
Daval, JL
中科院分区：
文献类型：
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作者：
Bossenmeyer-Pourié, C;Daval, JL
研究了1小时缺氧预处理对培养的胎鼠前脑神经元的分子效应，并将其置于6小时缺氧诱导凋亡的环境中。在防止细胞凋亡的同时，预处理导致活神经元数量增加，DNA合成增加，Bcl-2持续过表达和增殖细胞核抗原（PCNA）。适应性机制可能涉及抗凋亡蛋白和细胞周期调节因子，最终促进神经元增殖。(C) 1998 Elsevier Science B.V.版权所有
Molecular effects of pre-conditioning by 1-h hypoxia were investigated in cultured neurons from fetal rat forebrain, submitted the following day to a 6-h hypoxia that induces apoptosis. While preventing from apoptosis, pre-conditioning led to increased number of living neurons, DNA synthesis, with persistent overexpression of Bcl-2 and proliferating cell nuclear antigen (PCNA). Adaptative mechanisms would involve anti-apoptotic proteins and regulators of the cell cycle, to finally promote neuronal proliferation. (C) 1998 Elsevier Science B.V. All rights reserved.