Inhibitory effect of jaceosidin isolated from Artemisia argyi on the function of E6 and E7 oncoproteins of HPV 16
Inhibitory effect of jaceosidin isolated from Artemisia argyi on the function of E6 and E7 oncoproteins of HPV 16
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DOI：
10.1016/j.jep.2005.01.054
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发表时间：
2005-04-26
影响因子：
5.4
通讯作者：
Yoon, DY
中科院分区：
文献类型：
--
作者：
Lee, HG;Yu, KA;Yoon, DY
Jaceosidin（4 '，5，7-trihydroxy-3'，6-dimethoxyflavone）是从艾蒿中分离得到的一种推定的癌基因抑制剂。Jaceosidin抑制人乳头瘤病毒癌蛋白E6和p53肿瘤抑制蛋白之间的结合。此外，jaceosidin抑制E7癌蛋白和Rb肿瘤抑制蛋白之间的结合，也抑制HPV-16携带宫颈癌细胞，包括SiHa和CaSki的功能。总的来说，jaceosidin抑制人乳头瘤病毒的E6和E7癌蛋白的功能，这表明该化合物可用作治疗与人乳头瘤病毒相关的宫颈癌的潜在药物。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
Jaceosidin (4',5,7-trihydroxy-3',6-dimethoxyflavone) was isolated from Artemisia argyi as a putative oncogene inhibitor. Jaceosidin inhibited binding between oncoprotein E6 of the human papillomavirus and the p53 tumor suppressor protein. In addition, jaceosidin inhibited binding between the E7 oncoprotein and the Rb tumor suppressor protein, and also inhibited the function of HPV-16 harboring cervical cancer cells, including SiHa and CaSki. Collectively, jaceosidin inhibited the functions of the E6 and E7 oncoproteins of the human papillomavirus, suggesting that this compound might be used as a potential drug for the treatment of cervical cancers associated with the human papillomavirus. (c) 2005 Elsevier Ireland Ltd. All rights reserved.