Compression-induced damage and internal tissue strains are related
Compression-induced damage and internal tissue strains are related
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DOI：
10.1016/j.jbiomech.2008.09.016
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发表时间：
2008-12-05
影响因子：
2.4
通讯作者：
Oomens, C. W. J.
中科院分区：
文献类型：
--
作者：
Ceelen, K. K.;Stekelenburg, A.;Oomens, C. W. J.
骨突起附近软组织的长期机械负荷可导致肌肉组织退行性变，导致一种称为压力相关深层组织损伤的情况。这种类型的深压性溃疡可发展成严重的伤口，与愈合问题和预后变化有关。对潜在损害途径的有限知识阻碍了有效的预防策略和早期发现。传统上，压力性缺血被认为是引发损伤的主要病因。然而，最近的研究提出，组织变形本身是引发压力诱导的深层组织损伤的另一个候选因素。本研究对不同应变参数作为深部组织损伤通用预测指标的适用性进行了评价。通过结合动物-实验数值方法，我们表明，一旦超过应变阈值，随着最大剪切应变的增加，损伤会出现可重复的单调增加。这种最大剪切应变和损伤之间的关系似乎反映了内在的肌肉特性，因为它适用于相当多的实验。这一发现证实了组织变形本身在深层组织损伤的病因学中是重要的。通过专门的有限元建模，可以大大减少固有的生物变异，从而提出肌肉变形可以证明是损伤的通用预测指标。(C) 2008 Elsevier Ltd版权所有。
Prolonged mechanical loading of soft tissues adjacent to bony prominences can lead to degeneration of muscle tissue, resulting in a condition termed pressure-related deep tissue injury. This type of deep pressure ulcers can develop into a severe wound, associated with problematic healing and a variable prognosis. Limited knowledge of the underlying damage pathways impedes effective preventive strategies and early detection. Traditionally, pressure-induced ischaemia has been thought to be the main aetiological factor for initiating damage. Recent research, however, Proposes tissue deformation per se as another candidate for initiating pressure-induced deep tissue injury. In this study, different strain parameters were evaluated on their suitability as a generic predictive indicator for deep tissue injury. With a combined animal-experimental numerical approach, we show that there is a reproducible monotonic increase in damage with increasing maximum shear strain once a Strain threshold has been exceeded. This relationship between maximum shear strain and damage seems to reflect an intrinsic Muscle property, as it applied across a considerable number of the experiments. This finding confirms that tissue deformation per se is important in the aetiology of deep tissue injury. Using dedicated finite element modeling, a considerable reduction in the inherent biological variation was obtained, leading to the Proposal that muscle deformation can prove a generic predictive indicator of damage. (C) 2008 Elsevier Ltd. All rights reserved.