ORIGINAL ANTIGENIC SIN PHENOMENON IN EXPERIMENTAL FLAVIVIRUS INFECTIONS OF GUINEA-PIGS - STUDIES BY ENZYME-LINKED IMMUNOSORBENT-ASSAY
ORIGINAL ANTIGENIC SIN PHENOMENON IN EXPERIMENTAL FLAVIVIRUS INFECTIONS OF GUINEA-PIGS - STUDIES BY ENZYME-LINKED IMMUNOSORBENT-ASSAY
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DOI：
10.1111/j.1348-0421.1984.tb00709.x
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发表时间：
1984-01-01
影响因子：
2.6
通讯作者：
TSURUKUBO, Y
中科院分区：
文献类型：
--
作者：
INOUYE, S;MATSUNO, S;TSURUKUBO, Y
用2种密切相关的黄病毒（日本脑炎病毒和西尼罗河病毒）依次感染豚鼠，通过酶联免疫吸附试验（ELISA）和血凝抑制试验（HI）研究其抗体反应。ELISA检测结果均显示原始的抗原单克隆抗体反应，第二次感染后血清对第一次感染病毒的抗体活性高于第二次感染病毒。通过HI获得的结果是可变的。
Guinea pigs were sequentially infected with 2 closely related flaviviruses (Japanese encephalitis and West Nile viruses); their antibody responses were studied by enzyme-linked immunosorbent assay (ELISA) and hemagglutination-inhibition (HI). The results by ELISA always showed original antigenic sin responses: antibody activity of sera after the 2nd infection was higher to the 1st infecting virus than to the 2nd infecting virus. The results obtained by HI were variable.