Familial study of prostate cancer in Jamaica
Familial study of prostate cancer in Jamaica
复制标题
DOI：
10.1016/s0090-4295(98)00200-3
复制
发表时间：
1998-09-01
期刊：
影响因子：
2.1
通讯作者：
Walsh, PC
中科院分区：
文献类型：
--
作者：
Glover, FE;Coffey, DS;Walsh, PC
目标.牙买加金斯顿的前列腺癌发病率极高（1989年至1993年，每10万人中有300多人患前列腺癌）。本文讨论了牙买加前列腺癌的家族聚集性。家族性前列腺癌的早期证据是在犹他州摩门教人群中发现的。在随后的研究中一直观察到有前列腺癌家族史的男性患前列腺癌的风险增加。然而，很少有研究涉及黑人男性，众所周知，黑人男性患前列腺癌的风险总体较高。研究了263例经组织学证实的前列腺癌患者。263名年龄匹配的对照患者用于比较。获得了癌症患者和对照组的广泛家系。其他恶性肿瘤包括肺、乳腺、结肠、胃和子宫的数据也被收集。癌症患者和对照组在年龄和家庭规模方面具有可比性。30例癌症患者有一级亲属（即兄弟、父亲或儿子）患有前列腺癌，而对照组为15例。比值比为2.1（95%置信区间为1.1至4.4）。9例癌症患者有二级亲属（即祖父、孙子或叔叔）受影响，而对照组有3例。比值比为3.1（95%置信区间为0.8至17.8）。其他癌症的发病率在统计学上没有显著差异。在牙买加黑人男性中，前列腺癌的家族聚集性明显。一个一级亲属患有前列腺癌的男性患前列腺癌的可能性是普通人群的两倍。此外，如果一个人有一个二级亲属受到影响，那么患前列腺癌的风险可能存在统计学差异。泌尿学52：441-443，1998年。(C)1998年，Elsevier Science Inc. All rights reserved.
Objectives. Rates of prostate cancer in Kingston, Jamaica are extremely high (occurring in more than 300 men out of 100,000 in 1989 to 1993). This article addresses the familial aggregation of prostate cancer in Jamaica. Early evidence for familial prostate cancer was found in the Utah Mormon population. Increased risk of prostate cancer in men with a family history of prostate cancer has been consistently observed in subsequent studies. There have been few studies, however, involving black men, who are known to have an overall higher risk of developing prostate cancer.Methods. Two hundred sixty-three patients with prostate cancer documented by histology were studied. Two hundred sixty-three age-matched control patients were used for comparison. Extensive pedigrees were obtained for both patients with cancer and controls. Data on other malignancies including lung, breast, colon, stomach, and uterine were also collected.Results. The patients with cancer and the controls were comparable with respect to age and family size. Thirty patients with cancer had a first degree relative (ie, brother, father, or son) with prostate cancer compared to 15 controls. The odds ratio is 2.1 (95% confidence interval 1.1 to 4.4). Nine patients with cancer had a second degree relative (ie, grandfather, grandson, or uncle) affected compared to 3 controls. The odds ratio is 3.1 (95% confidence interval 0.8 to 17.8). There was no statistically significant difference in the rates of any of the other cancers studied.Conclusions. Familial aggregation of prostate cancer is clearly evident in black Jamaican men. A man with one first degree relative with prostate cancer is twice as likely as the general population to develop prostate cancer. In addition, there may be a statistical difference in the risk of developing prostate cancer if an individual has one second degree relative affected. UROLOGY 52: 441-443, 1998. (C) 1998, Elsevier Science Inc. All rights reserved.