DEVELOPMENTAL PROFILE OF NEURON-SPECIFIC (NSE) AND NON-NEURONAL (NNE) ENOLASE
DEVELOPMENTAL PROFILE OF NEURON-SPECIFIC (NSE) AND NON-NEURONAL (NNE) ENOLASE
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DOI：
10.1016/0006-8993(80)91168-3
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发表时间：
1980-01-01
期刊：
影响因子：
2.9
通讯作者：
GOODWIN, FK
中科院分区：
文献类型：
--
作者：
MARANGOS, PJ;SCHMECHEL, DE;GOODWIN, FK
成熟猕猴脑的神经元和神经胶质可以通过糖酵解酶烯醇化酶同工酶的含量来区分。神经元含有神经元特异性烯醇化酶（NSE），胶质细胞含有非神经元烯醇化酶（NNE）。对每只大鼠的测量表明，胚胎脑内NSE水平很低，随着神经元形态和功能的成熟而增加。NNE水平在胚胎期大脑中较高，在NSE首次出现时下降，随后逐渐上升到成人水平。与发展较快的脑区（脑干）相比，NSE水平在发育较长时间的脑区（前脑、小脑）中上升的速度较慢。在神经元发育过程中，从NNE向NSE的转换是一致的。在E60和E100猴脑组织中，含有较老神经元的区域NSE/NNE比值较高。从NNE到NSE的类似转换显然发生在猴子的神经元发育过程中。
Neurons and glia of mature Macaba mulatta brain can be distinguished by their isoenzyme content of the glycolytic enzyme enolase. Neurons contain neuron-specific enolase (NSE) and glial cells have non-neuronal enolase (NNE). Measurement of each rat shows that NSE levels are very low in embryonic brain and increase coincident with the morphological and functional maturation of neurons. NNE levels are high in embryonic brain and decrease when NSE 1st appears, followed by a gradual increase to adult levels. NSE levels rise at a slower rate in brain areas developing a more protracted period (forebrain, cerebellum) compared to areas developing more rapidly (brain stem). A switch from NNE to NSE during neuronal development is consistant. In E60 and E100 monkey brain tissue NSE/NNE ratios are higher in regions containing older neurons. A similar switch from NNE to NSE apparently occurs during neuronal development in monkey.