Manganese-Catalyzed Ring Opening of Benzofurans and Its Application to Insertion of Heteroatoms into the C2-O Bond.
Manganese-Catalyzed Ring Opening of Benzofurans and Its Application to Insertion of Heteroatoms into the C2-O Bond.
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DOI：
10.1021/acs.orglett.7b02660
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发表时间：
2017-09
期刊：
影响因子：
5.2
通讯作者：
Shun Tsuchiya;Hayate Saito;K. Nogi;H. Yorimitsu
中科院分区：
文献类型：
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作者：
Shun Tsuchiya;Hayate Saito;K. Nogi;H. Yorimitsu
在苯并呋喃转化为各种六元草杂环的芳香族变态反应中，已发展出一类新的芳香族变态反应。这种转化由两个反应组成：锰催化苯并呋喃的芳化或烷基化开环，提供重阴离子中间体，随后被多价杂原子亲电试剂捕获。含有硅、硼、磷、锗和钛的各种亲电试剂可用于这种杂原子插入。
A new class of aromatic metamorphosis in which benzofurans are converted into diverse six-membered oxaheterocycles has been developed. This transformation is composed of two reactions in one pot: manganese-catalyzed arylative or alkylative ring-opening of benzofurans affording dianionic intermediates and subsequent trapping with multivalent heteroatom electrophiles. Various electrophiles containing silicon, boron, phosphorus, germanium, and titanium could be applied to this heteroatom insertion.