Cortisol, inflammatory biomarkers and neurotrophins in children and adolescents with attention deficit hyperactivity disorder (ADHD) in Taiwan
Cortisol, inflammatory biomarkers and neurotrophins in children and adolescents with attention deficit hyperactivity disorder (ADHD) in Taiwan
复制标题
DOI：
10.1016/j.bbi.2020.05.017
复制
发表时间：
2020-08-01
影响因子：
15.1
通讯作者：
Pariante, Carmine M.
中科院分区：
文献类型：
--
作者：
Chang, Jane Pei-Chen;Mondelli, Valeria;Pariante, Carmine M.
背景：下丘脑-垂体-肾上腺（HPA）轴失调、炎症和神经营养物质失衡已被认为是注意缺陷多动障碍（ADHD）的主要症状，但目前尚无定论。摘要本研究旨在探讨台湾青少年ADHD患者与典型发展青少年（TD）在白天4个时间点的唾液皮质醇水平，以及早上血浆炎症生物标志物和神经营养因子的水平，并按年龄、ADHD亚型和对立违抗性障碍（ODD）合并症进行分层。方法：本研究采用病例对照研究方法，测定台湾青少年ADHD （n = 98，年龄6-18岁，平均年龄9.32 +/- 3.05岁）和TD （n = 21，年龄6-18岁，平均年龄9.19 +/- 2.96岁）患者在白天4个不同时间点（醒来、中午、1800小时和就睡前）的唾液皮质醇水平和早晨血浆炎症和神经营养因子生物标志物水平。结果：我们的研究表明，患有多动症的青少年睡前唾液皮质醇水平较低（效应值(ES) = -0.04, p = 0.023），而患有多动症合并形式（注意力不集中、多动和冲动都存在）的儿童醒来时唾液皮质醇水平最低。ADHD青少年的血浆高敏c反应蛋白（hs-CRP）和白细胞介素(IL)-6水平也较高(ES = 0.85-1.20, p
Background: Hypothalamus-Pituitary-Adrenal (HPA) axis dysregulation, inflammation and imbalance of neurotrophins have been suggested in attention deficit hyperactivity disorder (ADHD), but the results have not been conclusive. The aim of this study is to investigate the levels of salivary cortisol across 4-time points during the day, and of morning plasma inflammatory biomarkers and neurotrophins, in youth with ADHD and in typically developing youth (TD), with stratification by age, ADHD subtypes and oppositional defiant disorder (ODD) comorbidity in Taiwan.Methods: We conducted a case-control study measuring saliva cortisol levels at 4 different time points during the day (at awakening, noon, 1800 h and bedtime) and morning plasma levels of inflammatory and neurotrophins biomarkers in youth with ADHD (n = 98, age 6-18 years old with mean age 9.32 +/- 3.05 years) and TD (n = 21, age 6-18 years old with mean age 9.19 +/- 2.96 years) in Taiwan.Results: Our study showed that youth with ADHD had lower levels of bedtime salivary cortisol (effects size (ES) = -0.04, p =.023), with children with the combined form of the disorder (with inattention, hyperactivity and impulsivity all present) having the lowest awakening salivary cortisol levels. ADHD youth also had higher levels of plasma high-sensitivity C-reactive protein (hs-CRP) and interleukin (IL)-6 (ES = 0.85-1.20, p