Interacting oscillations in neural control of breathing: modeling and qualitative analysis.
Interacting oscillations in neural control of breathing: modeling and qualitative analysis.
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DOI：
10.1007/s10827-010-0281-0
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发表时间：
2011-06
影响因子：
1.2
通讯作者：
Rybak, Ilya A.
中科院分区：
文献类型：
--
作者：
Rubin, Jonathan E.;Bacak, Bartholomew J.;Molkov, Yaroslav I.;Shevtsova, Natalia A.;Smith, Jeffrey C.;Rybak, Ilya A.
关键词：
在哺乳动物呼吸中，随着代谢需求的增加（例如，在高碳酸血症、缺氧等期间）。这些振荡起源于后斜方核/面旁呼吸群（RTN/pFRG），并与BötC和pre-BötC复合体的相互作用神经群产生的呼吸振荡耦合，代表呼吸中枢模式发生器的核心。最近，我们分析了关于产生晚E振荡的实验数据，并提出了一个大规模的计算模型，该模型模拟了不同条件下BötC/pre-BötC和RTN/pFRG振荡之间可能的相互作用。在这里，我们描述了一个简化的模型，它保持了大规模模型的基本特征和架构，但依赖于简化的基于活动的神经种群描述。这种简化使我们能够使用动力系统理论的方法，例如快-慢分解、分叉分析和相平面分析，来阐明RTN/pFRG和BötC/pre-BötC振荡之间同步的机制和动力学。三个生理相关的行为进行了分析：出现和量子加速的晚E振荡在高碳酸血症，转换的晚E活动成双相E活动在高碳酸血症缺氧，量子减慢BötC/前BötC振荡与前BötC兴奋性的降低。每种行为都是由兴奋性驱动或其他模型参数的逐渐变化引起的，反映了代谢和/或生理条件的特定变化。我们的研究结果为RTN/pFRG和BötC/pre-BötC振荡之间的相互作用以及这些相互作用在不同代谢条件下控制呼吸的作用提供了重要的理论见解。
In mammalian respiration, late-expiratory (late-E, or pre-inspiratory) oscillations emerge in abdominal motor output with increasing metabolic demands (e.g., during hypercapnia, hypoxia, etc.). These oscillations originate in the retrotrapezoid nucleus/parafacial respiratory group (RTN/pFRG) and couple with the respiratory oscillations generated by the interacting neural populations of the Bötzinger (BötC) and pre-Bötzinger (pre-BötC) complexes, representing the kernel of the respiratory central pattern generator. Recently, we analyzed experimental data on the generation of late-E oscillations and proposed a large-scale computational model that simulates the possible interactions between the BötC/pre-BötC and RTN/pFRG oscillations under different conditions. Here we describe a reduced model that maintains the essential features and architecture of the large-scale model, but relies on simplified activity-based descriptions of neural populations. This simplification allowed us to use methods of dynamical systems theory, such as fast-slow decomposition, bifurcation analysis, and phase plane analysis, to elucidate the mechanisms and dynamics of synchronization between the RTN/pFRG and BötC/pre-BötC oscillations. Three physiologically relevant behaviors have been analyzed: emergence and quantal acceleration of late-E oscillations during hypercapnia, transformation of the late-E activity into a biphasic-E activity during hypercapnic hypoxia, and quantal slowing of BötC/pre-BötC oscillations with the reduction of pre-BötC excitability. Each behavior is elicited by gradual changes in excitatory drives or other model parameters, reflecting specific changes in metabolic and/or physiological conditions. Our results provide important theoretical insights into interactions between RTN/pFRG and BötC/pre-BötC oscillations and the role of these interactions in the control of breathing under different metabolic conditions.
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影响因子：
2.3
作者：
Iizuka, Makito;Fregosi, Ralph F.
通讯作者：
Fregosi, Ralph F.
影响因子：
5.3
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Guyenet, PG;Mulkey, DK;Bayliss, DA
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Bayliss, DA
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影响因子：
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作者：
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