Performance monitoring and stop signal inhibition in abstinent patients with cocaine dependence
Performance monitoring and stop signal inhibition in abstinent patients with cocaine dependence
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DOI：
10.1016/j.drugalcdep.2006.04.008
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发表时间：
2006-12-01
影响因子：
4.2
通讯作者：
Sinha, Rajita
中科院分区：
文献类型：
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作者：
Li, Chiang-Shan Ray;Milivojevic, Verica;Sinha, Rajita
冲动与滥用药物和旧病复发有关。作为冲动的一种衡量标准，物质滥用者在停止信号任务中的反应抑制比健康对照组受试者的反应抑制要弱。然而，除了反应抑制外，认知过程也会影响停止信号任务的成绩。对GO信号更好的响应准备增加了停止信号反应时间(SSRT)，而由停止信号引发的更好的性能监控降低了SSRT。因此，延长的SSRT可能反映了这些与任务相关的其他认知过程的差异，而不是反应抑制的受损。使用跟踪停止信号任务，我们比较了18名戒断可卡因依赖患者和41名年龄和教育程度匹配的健康对照组。我们根据赛马模型计算每个个体受试者的SSRT。我们还计算了前周期(FP)效应来衡量对GO信号的响应准备程度，并计算了后信号减速(PSS)效应来衡量对停止信号的监控性能。与健康对照组相比，可卡因受试者的SSRT增加，PSS效应降低。对PSS效应的协方差调整消除了健康对照组的SSRT差异。这些结果表明，表现监控减弱可能是可卡因依赖者反应抑制受损的关键认知机制。(C)2006爱思唯尔爱尔兰有限公司。保留所有权利。
Impulsivity has been associated with drug abuse and relapse. As a measure of impulsivity, response inhibition in a stop signal task is impaired in substance abusers compared to healthy control subjects. However, cognitive processes besides response inhibition can affect performance in the stop signal task. Greater response readiness to the go signal increases stop signal reaction time (SSRT) and greater performance monitoring elicited by the stop signal decreases SSRT. Prolonged SSRT, therefore, may reflect differences in these other task-related cognitive processes rather than impaired response inhibition. Using a tracking stop-signal task, we compared 18 abstinent cocaine dependent patients with 41 age- and education-matched healthy controls. We computed SSRT for each individual subject on the basis of the horse race model. We also computed the fore-period (FP) effect to measure response readiness to the go signal and the post-signal slowing (PSS) effect to measure performance monitoring to the stop signal. Cocaine subjects showed increased SSRT and decreased PSS effect, compared to healthy controls. Covariance adjustment for the PSS effect eliminated the SSRT difference from healthy controls. These results suggest that diminished performance monitoring can be a critical cognitive mechanism underlying impaired response inhibition in cocaine dependent patients. (c) 2006 Elsevier Ireland Ltd. All rights reserved.