Serum levels of the adipokine zinc-α2-glycoprotein are increased in chronic hemodialysis
Serum levels of the adipokine zinc-α2-glycoprotein are increased in chronic hemodialysis
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DOI：
10.1016/j.metabol.2010.06.019
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发表时间：
2011-05-01
影响因子：
9.8
通讯作者：
Fasshauer, Mathias
中科院分区：
文献类型：
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作者：
Philipp, Anne;Kralisch, Susan;Fasshauer, Mathias
锌-α2-糖蛋白（ZAG）最近被提议作为一种参与体重控制的新脂肪因子。在当前的研究中，我们通过比较慢性血液透析 (CD) 患者与对照组的循环 ZAG 水平来研究这种脂肪因子的肾脏消除。包括 60 名肾小球滤过率大于 50 mL/min 的 CD 患者和 60 名对照。采用酶联免疫吸附法测定ZAG的血清浓度；并在两组中研究其与肾功能、糖脂代谢、炎症的关系。与对照组 (48.3 +/- 23.5 mg/L) 相比，CD 患者的中位 ZAG 血清水平 (94.4 +/- 29.4 mg/L) 几乎高出 2 倍 (P < .001)。此外，在单变量分析中，循环 ZAG 与空腹胰岛素、胰岛素抵抗的稳态模型评估以及对照中的瘦素呈负相关。此外，CD 在多元回归分析中独立预测了 ZAG 浓度。肾滤过似乎是 ZAG 消除的重要途径，肾功能标志物应纳入 ZAG 生理学研究中。 (C) 2011 Elsevier Inc. 保留所有权利。
Zinc-alpha 2-glycoprotein (ZAG) has recently been proposed as a new adipokine involved in body weight control. In the current study, we investigated renal elimination of this adipokine by comparing circulating ZAG levels in patients on chronic hemodialysis (CD) with controls. Sixty CD patients and 60 controls with a glomerular filtration rate greater than 50 mL/min were included. Serum concentrations of ZAG were determined by enzyme-linked immunosorbent assay; and its relationship with renal function, glucose and lipid metabolism, as well as inflammation was studied in both groups. Median ZAG serum levels were almost 2-fold higher in CD patients (94.4 +/- 29.4 mg/L) as compared with controls (48.3 +/- 23.5 mg/L) (P < .001). Furthermore, circulating ZAG was negatively correlated with fasting insulin, homeostasis model assessment of insulin resistance, and leptin in controls in univariate analysis. Moreover, CD independently predicted ZAG concentrations in multiple regression analysis. Renal filtration appears to be an important route of ZAG elimination, and markers of renal function should be included in studies on ZAG physiology. (C) 2011 Elsevier Inc. All rights reserved.