Coronary microvascular dysfunction is associated with exertional haemodynamic abnormalities in patients with heart failure with preserved ejection fraction
Coronary microvascular dysfunction is associated with exertional haemodynamic abnormalities in patients with heart failure with preserved ejection fraction
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DOI：
10.1002/ejhf.2010
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发表时间：
2020-10-07
影响因子：
18.2
通讯作者：
Lerman, Amir
中科院分区：
文献类型：
--
作者：
Ahmad, Ali;Corban, Michel T.;Lerman, Amir
目的：本研究采用同步侵入性试验，独特地探讨了冠状动脉微血管功能与运动血流动力学之间的关系。方法和结果51例连续的不明原因的心力衰竭症状、非阻塞性冠状动脉疾病和正常左心室射血分数（>50%）的患者接受了血流动力学运动评估和同时进行的冠状动脉反应性测试。射血分数保留性心力衰竭（HFpEF）定义为静息时肺动脉楔压（PAWP）≥ 15 mmHg和/或运动峰值时≥ 25 mmHg。非内皮依赖性冠状动脉微血管功能障碍（CMD）定义为冠状动脉血流储备（CFR）
Aims This study uniquely explored the relationship between coronary microvascular function and exercise haemodynamics using concurrent invasive testing. Methods and results Fifty-one consecutive patients with unexplained cardiac exertion symptoms, non-obstructive coronary artery disease and normal left ventricular ejection fraction (>50%) underwent haemodynamic exercise assessment and concurrent coronary reactivity testing. Heart failure with preserved ejection fraction (HFpEF) was defined as a pulmonary arterial wedge pressure (PAWP) >= 15 mmHg at rest and/or >= 25 mmHg at peak exercise. Endothelium-independent coronary microvascular dysfunction (CMD) was defined as a coronary flow reserve (CFR)