Sinus floor elevation outcomes following perforation of the Schneiderian membrane. An experimental study in sheep
Sinus floor elevation outcomes following perforation of the Schneiderian membrane. An experimental study in sheep
复制标题
DOI：
10.1111/clr.12576
复制
发表时间：
2016-02-01
影响因子：
4.3
通讯作者：
Botticelli, Daniele
中科院分区：
文献类型：
--
作者：
Favero, Vittorio;Lang, Niklaus P.;Botticelli, Daniele
目的评估覆盖窦（Schneiderian）膜穿孔的胶原膜对窦底抬高结果（骨填充）的影响。材料和方法使用18只Pelibuey羊。动物上颌两侧均接受窦底抬高术。在两侧鼻窦粘膜上进行尺寸为5x4mm的穿孔，并在随机选择的测试部位放置胶原膜以覆盖穿孔。随后将双相磷酸钙移植物（60% HA/40% β-TCP）放置在两侧，并用聚乳酸和乙酰柠檬酸酯制成的膜封闭进入窗。愈合2周、4周和12周后进行处死。结果愈合2周后，增大的体积充满被结缔组织包围的生物材料，并且检测到最少的新骨。愈合 4 周后，发现新骨主要与窦骨壁相连，测试部位的百分比为 18.012.9%，对照部位的百分比为 12.3 +/- 7.9%。愈合 12 周后，与之前的愈合期相比，发现了相似数量的新骨，即测试部位和对照部位分别为 16.7 +/- 8.0% 和 13.7 +/- 10.1%，其中在窦腔底部检测到的数量最多。新形成的骨在窦腔内分布更均匀，包括中央区域。测试和对照部位之间的差异未达到统计学显着性。结论尽管在尺寸相对较小的窦粘膜穿孔上应用胶原膜时存在更多骨形成的趋势，但本研究未能确定这种手术在窦腔中实现骨填充的绝对必要性。
ObjectiveTo assess the influence of a collagen membrane covering a perforation of the sinus (Schneiderian) membrane on the outcome (bone fill) of a sinus floor elevation.Materials and MethodsEighteen Pelibuey sheep were used. The animals underwent sinus floor elevation on both sides of the upper jaw. A perforation of 5x4mm in dimension of the sinus mucosa was performed on both sides and, at a randomly selected test site, a collagen membrane was placed to cover the perforation. A graft of biphasic calcium phosphate (60% HA/40% beta-TCP) was subsequently placed bilaterally, and the access window was closed with a membrane made of polylactic acid and a citric acid ester acetyl. The sacrifices were performed after 2, 4, and 12weeks of healing.ResultsAfter 2weeks of healing, the augmented volume was filled with biomaterial surrounded by connective tissue and minimal new bone was detected. After 4weeks of healing, new bone was found mainly in connection with the sinus bony walls with percentages of 18.012.9% at the test and 12.3 +/- 7.9% at the control sites. After 12weeks of healing, similar amounts of newly formed bone were found compared to the previous healing period, namely 16.7 +/- 8.0% and 13.7 +/- 10.1% at the test and control sites, respectively, with the highest amount detected in the bottom of the sinus cavity. The newly formed bone was distributed more evenly within the sinus cavity also including the central areas. The differences between test and control sites did not reach statistical significance.ConclusionEven though there were trends for more bone formation when applying a collagen membrane on a sinus mucosal perforation of relatively small dimensions, this study failed to establish the absolute necessity of such a procedure to achieve bone fill in the sinus cavity.