Thyroid transcription factor-1 expression is an independent predictor of recurrence and correlates with the IASLC/ATS/ERS histologic classification in patients with stage I lung adenocarcinoma.
Thyroid transcription factor-1 expression is an independent predictor of recurrence and correlates with the IASLC/ATS/ERS histologic classification in patients with stage I lung adenocarcinoma.
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DOI：
10.1002/cncr.27863
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发表时间：
2013-03-01
期刊：
影响因子：
6.2
通讯作者：
Adusumilli, Prasad S.
中科院分区：
文献类型：
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作者：
Kadota, Kyuichi;Nitadori, Jun-ichi;Sarkaria, Inderpal S.;Sima, Camelia S.;Jia, Xiaoyu;Yoshizawa, Akihiko;Rusch, Valerie W.;Travis, William D.;Adusumilli, Prasad S.
我们研究了甲状腺转录因子-1（TTF-1）的表达是否与IASLC/ATS/ERS分类相关，以及它是否对I期肺腺癌患者的复发进行了分层。I期肺腺癌患者根据IASLC/ATS/ERS分类进行分类。我们构建了组织微阵列并对TTF-1进行了免疫染色;有452例病例可供分析。肿瘤通过核TTF-1表达的强度进行二分：阴性（评分0）或阳性（评分1-3）。累积复发率（CIR）用于估计复发概率。TTF-1在92%的所有患者中表达，包括100%的微创或以上皮为主的腺癌、94%的腺泡为主、98%的乳头状为主、93%的微乳头状为主、86%的实体为主、67%的胶体为主和47%的浸润性粘液腺癌。TTF-1表达阴性患者的CIR（n = 34; 5年CIR，40%）显著高于TTF-1表达阳性患者（n = 418; 5年CIR，15%; p < 0.001）。在中等级别肿瘤中，TTF-1阴性表达患者的CIR（n = 16; 5年CIR，45%）显著高于TTF-1阳性患者（n = 313，5年CIR，14%; p < 0.001）。在多变量分析中，TTF-1阴性表达与复发风险增加显著相关（风险比，2.55; p = 0.009）。TTF-1表达是复发的独立预测因子，将中等级别肿瘤分为2个预后亚组，并且与IASLC/ATS/ERS分类相关。
We investigated whether thyroid transcription factor–1 (TTF-1) expression correlates with the IASLC/ATS/ERS classification and whether it stratifies patients with stage I lung adenocarcinoma with respect to recurrence. Patients with stage I lung adenocarcinoma were classified according to the IASLC/ATS/ERS classification. We constructed tissue microarrays and performed immunostaining for TTF-1; 452 cases were available for analysis. Tumors were dichotomized by intensity of nuclear TTF-1 expression: negative (score 0) or positive (score 1–3). Cumulative incidence of recurrence (CIR) was used to estimate recurrence probabilities. TTF-1 expression was identified in 92% of all patients, including 100% of patients with minimally invasive or lepidic-predominant adenocarcinoma, 94% of acinar-predominant, 98% of papillary-predominant, 93% of micropapillary-predominant, 86% of solid-predominant, 67% of colloid-predominant, and 47% of invasive-mucinous. The CIR for patients with negative TTF-1 expression (n = 34; 5-year CIR, 40%) was significantly higher than that for patients with positive TTF-1 (n = 418; 5-year CIR, 15%; p < 0.001). Among the intermediate-grade tumors, the CIR for patients with negative TTF-1 expression (n = 16; 5-year CIR, 45%) was significantly higher than that for patients with positive TTF-1 (n = 313, 5-year CIR, 14%; p < 0.001). In multivariate analysis, negative TTF-1 expression significantly correlated with increased risk of recurrence (hazard ratio, 2.55; p = 0.009). TTF-1 expression is an independent predictor of recurrence, stratifying intermediate-grade tumors into 2 prognostic subsets, and it correlates with the IASLC/ATS/ERS classification.
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影响因子：
20.4
作者：
Anami, Yoichi;Iijima, Tatsuo;Noguchi, Masayuki
通讯作者：
Noguchi, Masayuki
影响因子：
7.3
作者：
Perner, S.;Wagner, P. L.;Rubin, M. A.
通讯作者：
Rubin, M. A.
影响因子：
50.5
作者：
Berghmans, T.;Paesmans, M.;Sculier, J. -P.
通讯作者：
Sculier, J. -P.
DOI：
10.1158/1078-0432.ccr-11-2097
发表时间：
2012-04-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Dignam JJ;Zhang Q;Kocherginsky M
通讯作者：
Kocherginsky M
影响因子：
20.4
作者：
Goldstraw, Peter;Crowley, John;Sobin, Leslie
通讯作者：
Sobin, Leslie