Do not neglect calcium: a systematic review and meta-analysis (meta-regression) of its digestibility and utilisation in growing and finishing pigs.
Do not neglect calcium: a systematic review and meta-analysis (meta-regression) of its digestibility and utilisation in growing and finishing pigs.
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DOI：
10.1017/s0007114518000612
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发表时间：
2018-06
期刊：
影响因子：
--
通讯作者：
Kyriazakis I
中科院分区：
文献类型：
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作者：
Misiura MM;Filipe JAN;Walk CL;Kyriazakis I
生长猪的钙消化率和利用率尚不清楚，并且在日粮配方中通常被忽视。这不仅对其需求量的准确测定有影响，而且对其与其他营养素的相互作用也有影响。对已发表的试验进行了系统回顾和荟萃分析（荟萃回归），以量化影响钙吸收和利用的因素，并得出钙内源排泄的估计值。该分析是根据 40 项研究的数据进行的，对应于对 1204 头猪进行的 201 次治疗。结果表明，虽然Ca吸收和保留（g/kg体重/天）随着Ca摄入量（P<0·001）、非植酸磷摄入量（P<0·001）和外源植酸酶补充（P<0·001）的增加而增加，但这些值随着植酸磷摄入量的增加而降低（P<0·05）。还检测到外源植酸酶和钙摄入量之间的相互作用，表明该酶的功效降低（P<0·001），以及植酸磷摄入量和外源植酸酶之间的相互作用，抵消了植酸磷对钙吸收和保留的直接负面影响（P<0·05）。没有动物相关特征的影响，例如猪基因型对钙吸收和保留的影响。 Ca 吸收 (90%) 和保留 (91%) 所解释的大量方差支持了我们对自变量的选择。通过线性回归获得的内源性 Ca 损失为 239 mg/kg DM 摄入量 (95% CI 114, 364)。这些结果增进了目前对钙消化率和利用的理解，并应有助于建立可消化钙的要求。因此，如果使用可消化钙值来估计钙需求量，猪日粮的配制将会更加正确。
Ca digestibility and utilisation in growing pigs are not well understood, and are usually neglected in diet formulation. This has implications not only for the accurate determination of its requirements but also for its interactions with other nutrients. A systematic review and meta-analysis (meta-regression) of published trials was carried out to quantify factors affecting Ca absorption and utilisation, and to derive an estimate of Ca endogenous excretion. The analysis was carried out on the data from forty studies, corresponding to 201 treatments performed on 1204 pigs. The results indicated that although Ca absorption and retention (g/kg of body weight per d) increased with increasing Ca intake (P<0·001), non-phytate-P intake (P<0·001) and exogenous phytase supplementation (P<0·001), these values decreased with increasing phytate-P intake (P<0·05). Interactions between exogenous phytase and Ca intake, indicating reduced efficacy of this enzyme (P<0·001), and between phytate-P intake and exogenous phytase, counteracting the direct negative effect of phytate-P (P<0·05) on Ca absorption and retention, were also detected. There were no effects of animal-related characteristics, such as pig genotype in Ca absorption and retention. The large amount of variance explained in Ca absorption (90 %) and retention (91 %) supported our choice of independent variables. Endogenous Ca losses obtained via linear regression were 239 mg/kg of DM intake (95 % CI 114, 364). These outcomes advance the current understanding of Ca digestibility and utilisation, and should contribute towards establishing requirements for digestible Ca. Consequently, pig diets will be more correctly formulated if digestible Ca values are used in estimating requirements for Ca.