Floral asymmetry involves an interplay between TO and MYB transcription factors in Antirrhinum
Floral asymmetry involves an interplay between TO and MYB transcription factors in Antirrhinum
复制标题
DOI：
10.1073/pnas.0501340102
复制
发表时间：
2005-04-05
影响因子：
11.1
通讯作者：
Coen, E
中科院分区：
文献类型：
--
作者：
Corley, SB;Carpenter, R;Coen, E
为了了解基因如何控制花的不对称，我们分离并分析了金鱼草中放射状(RAD)基因的作用。我们发现RAD基因编码一种小的MYB样蛋白，该蛋白在发育中的花的背部区域特异表达。RAID有一个MYB样结构域，与DIV的两个MYB样结构域中的一个密切相关，DIV是一种在花发育过程中对RAD具有拮抗作用的蛋白质。RAD和其他基因之间的相互作用表明，花的不对称性取决于两对转录因子之间的相互作用。首先，一对TO蛋白在花分生组织的背侧区域表达，导致背侧区域的RAD激活。然后，RAIDMYB样蛋白拮抗相关的DIV MYB样蛋白，阻止DIV在背部区域的活性。除了在背侧区域发挥作用外，RAD还通过RAD蛋白运动直接或通过信号分子间接作用于外侧区域。
To understand how genes control floral asymmetry, we have isolated and analyzed the role of the RADIALIS (RAD) gene in Antirrhinum. We show that the RAD gene encodes a small MYB-like protein that is specifically expressed in the dorsal region of developing flowers. RAID has a single MYB-like domain that is closely related to one of the two MYB-like domains of DIV, a protein that has an antagonistic effect to RAD on floral development. Interactions between RAD and othergenes indicate that floral asymmetry depends on the interplay between two pairs of transcription factors. First, a pair of TO proteins is expressed in dorsal regions of the floral meristem, leading to the activation of RAD in the dorsal domain. The RAID MYB-like protein then antagonizes the related DIV MYB-like protein, preventing DIV activity in dorsal regions. In addition to its role in dorsal regions, RAD acts nonautonomously on lateral regions either directly, through RAD protein movement, or indirectly, through a signaling molecule.