Population impact of preterm birth and low birth weight on developmental disabilities in US children.
Population impact of preterm birth and low birth weight on developmental disabilities in US children.
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DOI：
10.1016/j.annepidem.2016.02.012
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发表时间：
2016-04
影响因子：
5.6
通讯作者：
Rosenberg D
中科院分区：
文献类型：
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作者：
Schieve LA;Tian LH;Rankin K;Kogan MD;Yeargin-Allsopp M;Visser S;Rosenberg D
尽管之前的研究表明不良围产期结局与发育障碍 (DD) 之间存在关联，但对人口影响的研究有限。我们计算了社会人口学因素和组成部分的相对风险调整（aRR），并计算了极低出生体重（VLBW，所有早产）、中度低出生体重（MLBW）+早产、足月MLBW、正常出生体重（NBW）+早产和七个DD（脑瘫[CP]、自闭症谱系障碍[ASD]、智力障碍[ID]、行为行为之间的关联的人口归因分数（PAF）。 2011-2012 年全国儿童健康调查显示 3-17 岁儿童中存在的障碍、注意力缺陷多动障碍 [ADHD]、学习障碍 [LD] 和其他发育迟缓）。 VLBW-早产儿、MLBW-早产儿和 NBW-早产儿与 CP 强至中度相关（aRR：分别为 43.5、10.1 和 2.2；均显着），并且还与 ID、ASD、LD 和其他发育迟缓相关（aRR 范围：VLBW-早产儿 2.8-5.3；MLBW-早产儿 1.9-2.8；和 NBW-早产儿1.6–2.3）。 CP 的早产和/或 LBW 的总 PAF 为 55%，ASD、ID、LD 和其他发育迟缓的 PAF 为 10%–20%，ADHD 和行为行为障碍的 PAF 低于 5%。无论我们将 DD 作为独立结果还是在解释 DD 共现的相互排斥的类别中进行评估，结果都是相似的。早产对儿童神经发育有相当大的影响。然而，不同 DD 类型的相关关联和人口影响差异很大。
Although previous studies demonstrate associations between adverse perinatal outcomes and developmental disabilities (DDs), study of population impacts is limited. We computed relative risks adjusted (aRRs) for sociodemographic factors and component and summary population attributable fractions (PAFs) for associations between very low birth weight (VLBW, all preterm births), moderately low birth weight (MLBW) + Preterm, MLBW at term, and normal birth weight (NBW) + Preterm and seven DDs (cerebral palsy [CP], autism spectrum disorder [ASD], intellectual disability [ID], behavioral-conduct disorders, attention-deficit-hyperactivity disorder [ADHD], learning disability [LD], and other developmental delay) among children aged 3–17 years in the 2011–2012 National Survey of Children’s Health. VLBW-Preterm, MLBW-Preterm and NBW-Preterm were strongly to moderately associated with CP (aRRs: 43.5, 10.1, and 2.2, respectively; all significant) and also associated with ID, ASD, LD, and other developmental delay (aRR ranges: VLBW-Preterm 2.8–5.3; MLBW-Preterm 1.9–2.8; and NBW-Preterm 1.6–2.3). Summary PAFs for preterm birth and/or LBW were 55% for CP, 10%–20% for ASD, ID, LD, and other developmental delay, and less than 5% for ADHD and behavioral-conduct disorders. Findings were similar whether we assessed DDs as independent outcomes or within mutually exclusive categories accounting for DD co-occurrence. Preterm birth has a sizable impact on child neurodevelopment. However, relative associations and population impacts vary widely by DD type.