Socioeconomic status inequalities in low-grade inflammation during childhood.
Socioeconomic status inequalities in low-grade inflammation during childhood.
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DOI：
10.1136/archdischild-2016-310837
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发表时间：
2016-11
影响因子：
5.2
通讯作者：
Yoon A
中科院分区：
文献类型：
--
作者：
Schmeer KK;Yoon A
在美国，家庭社会经济地位（SES）是儿童健康差异的重要来源。慢性压力是SES可能影响儿童生理的一种方式，并对以后的健康不平等产生影响。由于不同年龄段对压力源的暴露和易感性不同，这些过程在整个童年时期可能会有不同的作用。我们评估了家族SES与慢性应激反应的一种生物标志物--通过升高的C反应蛋白（CRP）检测到的低度炎症--之间的相关性，并评估了儿童年龄相关性的差异。我们使用来自国家健康和营养调查（NHANES）的全国代表性数据和Tobit回归模型来估计SES与CRP的相关性以及年龄对2-18岁儿童的调节作用。我们的样本仅限于CRP ≤ 10 mg/l，以关注低度炎症（N= 13，165）。父母学历低于高中的儿童的CRP比父母毕业于大学的儿童高35%;贫困儿童的CRP比家庭收入高的儿童高24%。当考虑到儿童的BMI时，低教育和贫困协会分别减少到19%和15%。儿童年龄的相互作用是负面的，父母的教育和家庭收入显着。这项研究提供了新的证据，表明SES与儿童的低度炎症有关，并且这些关联在儿童早期和中期可能特别强烈。未来的研究应该进一步了解与低家庭SES相关的压力源，这些压力源可能导致儿童期免疫系统失调。
Family socioeconomic status (SES) is an important source of child health disparities in the U.S. Chronic stress is one way SES may impact children’s physiology with implications for later health inequalities. These processes may work differently across childhood due to differences in exposure and susceptibility to stressors at different ages. We assess associations between family SES and one biomarker of chronic stress exposure—low grade inflammation detected by elevated C-reactive protein (CRP)—and evaluate differences in the associations by child age. We used nationally-representative data from the National Health and Nutrition Survey (NHANES) and Tobit regression models to estimate SES associations with CRP and the moderating effects of age for children ages 2–18 years. Our sample was limited to CRP ≤ 10 mg/l to focus on low-grade inflammation (N=13,165). Children whose parent had less than a high school degree had 35% higher CRP than those with a college-graduate parent; and, poor children had 24% higher CRP than those with high family income, net of controls. When children’s BMI was accounted for, low education and poverty associations were reduced to 19% and 15%, respectively. Child age interactions were negative and significant for both parental education and family income. This study provides new evidence that SES is associated with low-grade inflammation in children, and that these associations may be particularly strong during early and mid-childhood. Future research should further our understanding of stressors related to low family SES that may lead to immune system dysregulation during childhood.