Validation of the myocardial performance index by echocardiography in mice: A noninvasive measure of left ventricular function
Validation of the myocardial performance index by echocardiography in mice: A noninvasive measure of left ventricular function
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DOI：
10.1067/s0894-7317(03)00399-7
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发表时间：
2003-08-01
影响因子：
6.5
通讯作者：
Hohimer, AR
中科院分区：
文献类型：
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作者：
Broberg, CS;Pantely, GA;Hohimer, AR
背景心肌工作指数（MPI）是一种基于多普勒的左心室（LV）功能指标。它是无创的，独立于LV形状，并且不需要尺寸测量。然而，它从来没有在mice.Methods中被验证过：总共29只麻醉的小鼠用LV压力导管在基线和β-肾上腺素能张力、温度、前负荷和后负荷的操作期间进行超声心动图（2维、M模式和多普勒）。将左室压力对时间的最大导数（dP/dt（max））与MPI、短轴缩短率（FS）、环周纤维平均缩短速度和FS/MPI比值进行比较。结果：MPI（基线0.44 +/- 0.07）与dP/dt（max）（R = -.779，p < .001）密切相关，FS和环周纤维平均缩短速度也是如此。MPI与收缩性、前负荷和后负荷操作显著不同。FS/MPI与dP/dt（max）的相关性最好。结论：在一定的血流动力学条件下，MPI与dP/dt（max）密切相关。它可以作为一个非侵入性指标的左心室功能在这个物种。
Background The myocardial performance index (MPI) is a Doppler-based measure of left ventricular (LV) function. It is noninvasive, independent of LV shape, and does not require dimensional measurements. However, it has never been validated in mice.Methods: A total of 29 anesthetized mice with LV pressure catheters underwent echocardiography (2-dimensional, M-mode, and Doppler) at baseline and during manipulations of (beta-adrenergic tone, temperature, preload, and afterload. The maximum derivative of LV pressure with respect to time (dP/dt(max)) was compared with MPI, fractional shortening (FS),mean velocity of circumferential fiber shortening, and the FS/MPI ratio.Results: MPI (baseline 0.44 +/- 0.07) correlated strongly with dP/dt(max) (R = -.779, p < .001), as did FS and mean velocity of circumferential fiber shortening. MPI differed significantly with contractility, preload, and afterload manipulation. FS/MPI showed the best correlation with dP/dt(max).Conclusions: MPI strongly correlates with dP/dt(max) over a range of hemodynamic conditions in mice. It can be used as a noninvasive index of LV function in this species.