Chromosomal locations of human tissue plasminogen activator and urokinase genes.
Chromosomal locations of human tissue plasminogen activator and urokinase genes.
复制标题
人体组织纤溶酶原激活剂和尿激酶基因的染色体位置。
DOI：
10.1126/science.3840278
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Shows,TB
中科院分区：
文献类型：
--
作者：
Rajput,B;Degen,SF;Reich,E;Waller,EK;Axelrod,J;Eddy,RL;Shows,TB
利用一组人-鼠体细胞杂交和特异性互补DNA探针，将人组织型纤溶酶原激活剂和尿激酶基因分别定位于人类8号和10号染色体。这一结果与之前将纤溶酶原激活剂基因分配到6号染色体上的结果相反。由于肿瘤细胞产生高水平的纤溶酶原激活剂，有趣的是，8号染色体的异常与各种白血病和淋巴瘤有关，而且人类的两个癌基因c-mos和c-myc也被定位在8号染色体上。
A panel of human-mouse somatic cell hybrids and specific complementary DNA probes were used to map the human tissue plasminogen activator and urokinase genes to human chromosomes 8 and 10, respectively. This result is in contrast to a previous assignment of a plasminogen activator gene to chromosome 6. As neoplastic cells produce high levels of plasminogen activator, it is of interest that aberrations of chromosome 8 have been linked to various leukemias and lymphomas and that two human oncogenes, c-mosand c-myc, have also been mapped to chromosome 8.