TRANSGENIC PLANTS AS VACCINE PRODUCTION SYSTEMS
TRANSGENIC PLANTS AS VACCINE PRODUCTION SYSTEMS
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DOI：
10.1016/s0167-7799(00)88986-6
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发表时间：
1995-09-01
影响因子：
17.3
通讯作者：
ARNTZEN, CJ
中科院分区：
文献类型：
--
作者：
MASON, HS;ARNTZEN, CJ
表达具有工业或医药价值的外来蛋白质的转基因植物是发酵生产系统的一种经济替代方案。由于外来基因的瞬时或稳定表达，已经在植物中生产出特定的疫苗。最近的研究表明，编码细菌和病毒病原体抗原的基因可以在植物中以保留天然免疫原性的形式表达。表达细菌抗原的转基因马铃薯块茎作为食物时，可以刺激体液和粘膜免疫反应。这些结果为将植物用作生产疫苗的媒介提供了“概念证据”。
Transgenic plants that express foreign proteins with industrial or pharmaceutical value represent an economical alternative to fermentation-based production systems. Specific vaccines have been produced in plants as a result of the transient or stable expression of foreign genes. It has recently been shown that genes encoding antigens of bacterial and viral pathogens can be expressed in plants in a form in which they retain native immunogenic properties. Transgenic potato tubers expressing a bacterial antigen stimulated humoral and mucosal immune responses when they were provided as food. These results provide 'proof of concept' for the use of plants as a vehicle to produce vaccines.