Comparison of solvent extraction and supported liquid membrane permeation using an ionic liquid for concentrating penicillin G
Comparison of solvent extraction and supported liquid membrane permeation using an ionic liquid for concentrating penicillin G
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DOI：
10.1016/j.memsci.2006.11.046
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发表时间：
2007-02
影响因子：
9.5
通讯作者：
M. Matsumoto;Tokihito Ohtani;Kazuo Kondo
中科院分区：
文献类型：
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作者：
M. Matsumoto;Tokihito Ohtani;Kazuo Kondo
室温离子液体作为挥发性有机化合物的替代溶剂出现，这些有机化合物通常用于液-液萃取和液膜分离。本研究以咪唑基离子液体、1-正丁基-1-正己基和1-正辛基-3-甲基咪唑的六氟磷酸盐和三辛基甲基氯化铵(TOMAc)为离子液体。首先测定了青霉素G在缓冲溶液和离子液体之间的分配系数。虽然咪唑类离子液体能从缓冲水溶液中萃取青霉素G，但萃取率远低于传统的有机溶剂乙酸丁酯。虽然TOMAC的分配比与乙酸丁酯相当，但很难将青霉素G从TOMAC相中剥离出来。因此，将离子液体应用于支撑液膜体系。咪唑基离子液体可使青霉素G透过支撑液膜，但未观察到pH差驱动的上行转运。以TOMAc为膜溶液，以氯离子浓度差为渗透驱动力，实现了药物的上行转运。
Room temperature ionic liquids are emerging as alternative solvents for volatile organic compounds conventionally used in liquid–liquid extraction and liquid membrane separation. In this study, imidazolium-based ionic liquids, the hexafluorophosphates of 1-n-butyl-, 1-n-hexyl- and 1-n-octyl-3-methyl imidazolium, and trioctylmethylammonium chloride (TOMAC) were used as ionic liquids. First the distribution coefficient of penicillin G between the buffer solution and ionic liquids was measured. Although imidazolium-based ionic liquids can extract penicillin G from the buffer aqueous solution, the extent was much lower than using butyl acetate, the conventional organic solvent. While the distribution ratio with TOMAC was comparable to butyl acetate, it was difficult to strip penicillin G from the TOMAC phase. Therefore, ionic liquids were applied to the supported liquid membrane system. Penicillin G permeated through the supported liquid membrane with imidazolium-based ionic liquids but uphill transport driven by pH difference was not observed. Uphill transport was achieved by using TOMAC as a membrane solution and chloride concentration difference as a driving force of permeation.