Effects of a structured weight-bearing exercise program on bone metabolism among breast cancer survivors: a feasibility trial.
Effects of a structured weight-bearing exercise program on bone metabolism among breast cancer survivors: a feasibility trial.
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DOI：
10.3816/cbc.2010.n.030
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发表时间：
2010-06
影响因子：
3.1
通讯作者：
Morrow GR
中科院分区：
文献类型：
--
作者：
Peppone LJ;Mustian KM;Janelsins MC;Palesh OG;Rosier RN;Piazza KM;Purnell JQ;Darling TV;Morrow GR
乳腺癌治疗，特别是激素治疗，会加速乳腺癌幸存者的骨质流失 (BL)，导致骨质疏松症和骨折风险增加。太极拳 (TCC) 是一种中等程度的负重运动，相当于步行，已被证明可以提高乳腺癌幸存者的有氧能力和力量，也可能有效减缓乳腺癌幸存者的骨质流失。这项试点研究比较了 TCC 与标准支持疗法（ST；运动控制）对乳腺癌幸存者 BL 生物标志物的影响。随机分配的乳腺癌幸存者（N = 16；中位年龄 53 岁；治疗后 < 30 个月）完成 12 周（每周 3 次，每次 60 分钟）的 TCC 或 ST。在基线和干预后根据酶联免疫吸附测定法测定血清 I 型胶原 N-端肽（NTx）（骨吸收标志物）和骨特异性碱性磷酸酶（BSAP）（骨形成标志物）的水平。通过协方差分析，与 ST 组的幸存者（BSAP [μg/L]：之前，7.6；之后，8.1；变化，0.5 µg/L [6.3%]）相比，TCC 组的幸存者骨形成水平有更大的增加（BSAP [μg/L]：之前，8.3；之后，10.2；变化，1.9 µg/L 和 22.4%）。 TCC 组的幸存者骨吸收也显着下降（NTx [纳摩尔骨胶原当量；nmBCE]：之前，17.6；之后，11.1；变化，-6.5 nmBCE；-36.9%），而 ST 组的女性则没有（NTx [nmBCE]：之前，20.8；之后，18.8；变化，-2.0 nmBCE；-9.6%）。这项初步研究表明，负重运动通过增加骨形成和减少骨吸收对 BL 产生积极影响。有必要进一步检查 TCC 对骨骼健康的影响。
Treatments for breast cancer, specifically hormonal therapy, accelerate bone loss (BL) among breast cancer survivors, leading to osteoporosis and an increase in fracture risk. Tai Chi Chuan (TCC) is a moderate form of weight-bearing exercise, equivalent to walking, and it has been shown to improve aerobic capacity and strength among breast cancer survivors and might also be effective in slowing bone loss in breast cancer survivors. This pilot study compared the influence of TCC with that of standard support therapy (ST; exercise control) on BL biomarkers among breast cancer survivors. Randomly assigned breast cancer survivors (N = 16; median age, 53 years; < 30 months after treatment) completed 12 weeks (3 times per week, 60 minutes per session) of TCC or ST. Serum levels of N-telopeptides of type I collagen (NTx), a marker of bone resorption, and bone-specific alkaline phosphatase (BSAP), a marker of bone formation, were determined according to enzyme-linked immunosorbent assay at baseline and after the intervention. Using analysis of covariance, survivors in the TCC group experienced a greater increase in levels of bone formation (BSAP [µg/L]: before, 8.3; after, 10.2; change, 1.9 µg/L and 22.4%), compared with survivors in ST (BSAP [µg/L]: before, 7.6; after, 8.1; change, 0.5 µg/L [6.3%]). Survivors in the TCC group also experienced a significant decrease in bone resorption (NTx [nanomoles bone collagen equivalent; nmBCE]: before, 17.6; after, 11.1; change, −6.5 nmBCE; −36.9%), whereas women in the ST group did not (NTx [nmBCE]: before, 20.8; after, 18.8; change, −2.0 nmBCE; −9.6%). This pilot study suggests that weight-bearing exercise exerts positive effects on BL, through increased bone formation and decreased bone resorption. Further examinations of the influence of TCC on bone health are warranted.