Corticostriatal Field Potentials Are Modulated at Delta and Theta Frequencies during Interval-Timing Task in Rodents.
Corticostriatal Field Potentials Are Modulated at Delta and Theta Frequencies during Interval-Timing Task in Rodents.
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DOI：
10.3389/fpsyg.2016.00459
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发表时间：
2016
影响因子：
3.8
通讯作者：
Narayanan NS
中科院分区：
文献类型：
--
作者：
Emmons EB;Ruggiero RN;Kelley RM;Parker KL;Narayanan NS
及时组织运动是哺乳动物行为的一个重要且高度保守的特征。动作的时间控制需要皮质纹状体网络。我们使用两个间隔计时任务研究啮齿类动物的这些网络，同时记录内侧额叶皮层（MFC）或背内侧纹状体中的 LFP。与之前的工作一致，我们发现线索触发的 delta（1-4 Hz）和 theta 活动（4-8 Hz）主要存在于啮齿动物 MFC 中。我们观察到 MFC 和背内侧纹状体跨时间间隔的 delta 活动。奖励反应与 MFC 中 delta 活性的增加相关。 MFC 中的 θ 带和纹状体中的 delta 带的活动与反应时间相关。这些数据表明，额纹状体网络中的 δ 和 θ 活动在间隔时间期间受到调节，并且这些带中的活动可能涉及动作的时间控制。
Organizing movements in time is a critical and highly conserved feature of mammalian behavior. Temporal control of action requires corticostriatal networks. We investigate these networks in rodents using a two-interval timing task while recording LFPs in medial frontal cortex (MFC) or dorsomedial striatum. Consistent with prior work, we found cue-triggered delta (1–4 Hz) and theta activity (4–8 Hz) primarily in rodent MFC. We observed delta activity across temporal intervals in MFC and dorsomedial striatum. Rewarded responses were associated with increased delta activity in MFC. Activity in theta bands in MFC and delta bands in the striatum was linked with the timing of responses. These data suggest both delta and theta activity in frontostriatal networks are modulated during interval timing and that activity in these bands may be involved in the temporal control of action.